Abstract
Gianotti–Crosti syndrome (GCS) consists of a sudden eruption of small papules or papulovesicles over the face, buttock and extensor surfaces of limbs, generalized lymphadenopathy and acute nonicteric hepatitis in young children. Most early cases were caused by hepatitis B virus. Adults could also suffer from GCS. Other viruses may now be more pertinent than hepatitis B virus. The authors no longer need lymphadenopathy or hepatitis to make a diagnosis. The disease is self-limiting. Complications are uncommon. The inclusion and exclusion criteria of studies in GCS are nonuniform, rendering low homogeneity of study subjects. A validated diagnostic criteria would allow subjects in all studies more homogenous so that valid meta-analyses and systemic reviews can be performed. Data from subjects with GCS seen in specialist settings only might be biased. Recruitment in primary care settings with specifically trained primary care physicians and application of a valid and standardized diagnostic criteria might be considered.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Notes
Data taken from Citation[65,66].
Reprinted with permission from Citation[65]. © (2001), Quadrant HealthCom Inc.