Pediatric dental sedation: challenges and opportunities

Abstract

High levels of dental caries, challenging child behavior, and parent expectations support a need for sedation in pediatric dentistry. This paper reviews modern developments in pediatric sedation with a focus on implementing techniques to enhance success and patient safety. In recent years, sedation for dental procedures has been implicated in a disproportionate number of cases that resulted in death or permanent neurologic damage. The youngest children and those with more complicated medical backgrounds appear to be at greatest risk. To reduce complications, practitioners and regulatory bodies have supported a renewed focus on health care quality and safety. Implementation of high fidelity simulation training and improvements in patient monitoring, including end-tidal carbon dioxide, are becoming recognized as a new standard for sedated patients in dental offices and health care facilities. Safe and appropriate case selection and appropriate dosing for overweight children is also paramount. Oral sedation has been the mainstay of pediatric dental sedation; however, today practitioners are administering modern drugs in new ways with high levels of success. Employing contemporary transmucosal administration devices increases patient acceptance and sedation predictability. While recently there have been many positive developments in sedation technology, it is now thought that medications used in sedation and anesthesia may have adverse effects on the developing brain. The evidence for this is not definitive, but we suggest that practitioners recognize this developing area and counsel patients accordingly. Finally, there is a clear trend of increased use of ambulatory anesthesia services for pediatric dentistry. Today, parents and practitioners have become accustomed to children receiving general anesthesia in the outpatient setting. As a result of these changes, it is possible that dental providers will abandon the practice of personally administering large amounts of sedation to patients, and focus instead on careful case selection for lighter in-office sedation techniques.

Keywords:

• conscious sedation
• anesthesia
• general
• pediatrics

Introduction

The developing child often lacks the coping skills necessary to navigate the dental experience, making provision of quality dental care to children challenging. While unrestored caries may contribute to pain, disordered sleep, difficulty learning, and poor growth in children, unpleasant dental experiences can cause psychologic harm.^1–3 Most dental anxiety develops in childhood as a result of frightening and painful dental experiences. If appropriate precautions are not taken, dental treatment may overwhelm the child, resulting in dental fear and avoidance.⁴ These fears persist into adulthood, causing 10%–20% of the US population to avoid necessary dental care.^5,6 Sedation reduces such complications and instills trust in the family and child.

Today, it is estimated that 100,000–250,000 pediatric dental sedations are performed each year in the USA, and practitioners anticipate a need for more pharmacologic behavior management in the future.^7,8 High levels of pediatric dental disease, increasingly difficult child behavior, and parent expectations support a need for sedation services.^8–11 Here we review common challenges that contemporary dental practitioners experience and suggest possible solutions.

Risk factors for adverse events

Sedation is a continuum. Physiologic effects vary significantly depending upon a variety of factors, including medication, dose, delivery route, and patient characteristics.^12,13 Minimal sedation is considered to be the mildest form of sedation. As stronger medications and higher doses are administered, the depth of sedation shifts toward moderate sedation, deep sedation, and possibly even general anesthesia. At more profound levels, patients become unresponsive and incapable of maintaining their own breathing or cardiovascular function.^14,15 In adult dental practice, titration of sedation depth through intravenous drug administration is common. In pediatrics, however, due to behavioral constraints, sedation by bolus oral administration is well tolerated and routine.^7,13 With oral administration, sedation depth can be difficult to predict and titration is not possible.¹⁶ Consequently, over-sedation and respiratory obstruction can occur. Should this happen, it is the responsibility of the sedation provider to manage the unconscious child until she or he regains the ability to self-regulate.

Sedation for dental procedures has been implicated in a disproportionate number of cases that resulted in death or permanent neurologic damage.^17–19 When causes of sedation-related injury and death in outpatient settings have been reviewed, damage almost always resulted from an inability to resuscitate once a patient lost protective reflexes.^17,18,20,21 Children under 5 years of age and those with pre-existing medical conditions appear to be at greatest risk.^17,18,21 These findings have led to increased scrutiny of pediatric dental sedation by the public and the medical community.^20,22 One concern is that dentists and other non-anesthesiologist practitioners receive varying levels of sedation training and often do not practice in settings with immediate access to rescue resources such as a code team. In contrast, anesthesiologists receive relatively uniform training and practice the skills required to rescue patients on a daily basis. They also commonly practice in an operating room environment and have the ability to request backup when needed.

Patient monitoring

Early efforts to provide sedation in the dental office were largely unregulated, and clinicians primarily relied only on direct physical findings such as quality of respiration and patient color to assess the sedated patient. Over time technology improved, and professional associations and regulatory bodies provided a framework for safe and effective practice.^16,23,24 Advancements included monitoring patients with blood pressure monitors and precordial stethoscopes. With the advent of pulse oximetry, electronic monitoring of blood oxygen saturation further increased safety. This allowed for continuous monitoring of heart rate and blood oxygen saturation, with alarm activation when blood pressure or oxygenation declined below a threshold value. In contemporary practice, end-tidal carbon dioxide (E_tCO₂) monitors have become standard in operating rooms to monitor apnea and hypoventilation.

In response to growing safety concerns, E_tCO₂ monitoring is now used increasingly in ambulatory settings^17,18,20,25 (Figure 1). Professional association guidelines reflect this trend, and the American Society of Anesthesiologists has amended its standards for basic anesthetic monitoring to require E_tCO₂ for moderate or deep sedation.²⁵ In dentistry, perhaps the most widely recognized professional sedation guidelines come from the American Dental Association. For children 12 years of age and under, the American Dental Association recognizes the American Academy of Pediatrics/American Academy of Pediatric Dentistry (AAP/AAPD) guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Both the American Dental Association and the AAP/AAPD guidelines suggest that E_tCO₂ monitoring may be used to evaluate respiration; however, it is not currently required for moderate sedation.^16,26 In the USA, each state has unique requirements for a dentist to perform sedation. States vary considerably regarding training standards, required continuing education, and advanced life support credentials required to maintain a sedation permit.²⁷ Similarly, there is no nationally recognized government standard for monitoring of dental patients during sedated procedures. However, some states have begun to mandate the use of E_tCO₂ monitors for dental sedation. Given this trend, it is possible that in the future E_tCO₂ monitoring will become the standard for sedated patients in dental offices and health care facilities.

Figure 1 Nitrous oxide nasal hood modified for use with an end-tidal carbon dioxide sampling line.

Modern drugs and routes

Selection of medications is a critical component of the sedation plan. When possible, consideration should be given to sedatives with available reversal agents. In the event of oversedation, benzodiazepine and narcotic medications may be preferred over drugs without known reversal agents, such as chloral hydrate. In recent years, both the solution and capsule form of chloral hydrate have been withdrawn from the US market. In the future, in spite of its historic success, chloral hydrate will likely continue to fall out of favor for pediatric dental sedation.

Oral sedation is the most popular route of administration among pediatric dentists.^28,29 However, this route is notoriously unpredictable, and frustration often arises when children refuse to accept the sedative medication.^28,30 Efforts have been made to mask the bitter taste of the oral medications; however, it is not uncommon for children to spit or regurgitate them. On the other hand, placement of an intravenous cannula for parenteral sedation can be traumatic to children.³⁰ New methods of medication delivery have been proposed and investigated. One alternative is the transmucosal (intranasal, sublingual, buccal) route. The benefits of this route include direct absorption of drugs into the systemic circulation, avoidance of hepatic first pass metabolism, increased bioavailability, and faster onset compared with oral sedation. Transmucosal administration also results in less discomfort than intravenous sedation and better acceptance by patients.²⁸

Intranasal administration of midazolam has been proven to be a safe and effective sedative for short procedures and is widely used by pediatric dentists.^29–36 In addition to quick onset, a relatively quick recovery has also been suggested.³⁴ Some believe that another possible advantage of intranasal sedation is that a strict adherence to fasting requirements may not be essential.^28,32,37 This is a controversial area; however, results of clinical trials suggest that children may be given intranasal midazolam with less risk of nausea, vomiting, and respiratory complications.^32,37 While practitioners should be cautious in relaxing recognized safety standards, given the appropriate setting (such as a hospital emergency room), this technique may prove useful for uncooperative children who need emergency treatment and have eaten.

Although intranasal administration is usually simple, relatively painless, and requires less patient cooperation, it has been associated with mucosal irritation. This may lead to coughing, sneezing, crying and the expulsion of part of the dose. This is particularly true when a large volume of the drug is applied.^34,36 Therefore, careful administration is critical. When administration of intranasal midazolam by drop and aerosolized form were compared, aerosolization was better tolerated and led to less aversive behavior²⁹ (Figure 2).

Figure 2 Child receiving intranasal midazolam using an aerosolization device.

Nasal mucosal secretions can also affect intranasal drug absorption. The buccal mucosa has a rich blood supply and is relatively permeable, yielding pharmacokinetics that are similar to intranasal administration. It therefore appears to be an attractive alternative to the intranasal route.³⁸ Buccal administration of aerosolized midazolam has been proven to be safe, effective, and well accepted by young patients.^28,39,40 An oral solution may also be used in place of aerosol spray; however, the possibility of experiencing the bitter taste increases, leading to poor patient acceptance.⁴⁰ Buccal and intranasal midazolam have the same maximum working time while intranasal has a faster onset time. Intranasal midazolam also elicited less crying and produced a greater proportion of patients with optimal sedation scores.⁴¹ Chopra et al and Klein et al reported better acceptance of the buccal route,^28,39 while Sunbul et al found intranasal midazolam to be more acceptable to children.⁴¹ Interestingly, even though it was poorly tolerated by subjects during administration, in one study a greater proportion of parents preferred the intranasal route for future sedation.³⁹

Dexmedetomidine is a selective alpha2-adrenergic agonist that provides sedative, anxiolytic, and analgesic properties without causing respiratory depression.^42,43 It was approved by US Food and Drug Administration to be used for sedation in adults in the intensive care setting in 1999. Due to its efficacy in adults, in recent years it has been introduced into the pediatric population for procedural sedation outside the operating room. Dexmedetomidine is available in intranasal, buccal, or oral form.⁴³ The safe use of dexmedetomidine in pediatric diagnostic radiology has been well documented.⁴² However, studies on its use for outpatient dental procedures are limited, especially in children. In a pilot study by Hitt et al, intranasal delivery of sufentanil and dexmedetomidine provided acceptable sedation without respiratory depression or major complications in 20 children undergoing dental procedures.⁴⁴

When reviewing the small clinical trials and observational studies exploring pediatric use of dexmedetomidine, it is important to note that all these studies were performed in a medically controlled setting under the supervision of anesthesiologists.^44–46 Clearly, much work needs to be done to define the efficacy of dexmedetomidine and its impact on pediatric dental sedation. However, due to its unique characteristics and lack of respiratory depression, this medication holds great promise as an alternative option for sedation in the pediatric dental clinic.

Optimizing care for patient safety

Risk is inherent in procedural sedation. While it is impossible to eliminate risk entirely, negative outcomes can be minimized by optimizing work systems and eliminating human factors for error.^47–49 We also reduce the chance of future incidents by recognizing accidents that were avoided but nearly occurred. These “near misses” should be reported so that contributing factors can be analyzed and eliminated.⁵⁰

The greatest successes are achieved by focusing on safety before the sedation appointment. Preparation begins with appropriate case selection. Using a standard form for presedation, patient assessment helps eliminate guesswork (Figure 3). Appropriate assessment includes patient medical history, physical examination (including targeted airway assessment), and assignment of an American Society of Anesthesiologists score.^51,52 Similarly, in-office sedation should be limited to healthy children. Healthy children and those with mild systemic disease (American Society of Anesthesiologists score I and II) can generally be cared for safely and effectively in the dental clinic. Complicated medical conditions including heart disease, obstructive sleep apnea, and obesity have been shown to increase sedation risk and the chances of failed sedation.⁵³ These factors must be considered carefully when selecting the sedation regimen and venue.

Figure 3 A presedation checklist.¹³

Note: The ASA classification system is a health-grading system used commonly by medical and dental providers. ASA I = healthy, ASA II = mild systemic disease.
Abbreviations: Hx, history; Tx, treatment; M, male; F, female; ASA, American Society of Anesthesiologists.

Appropriate dosing is another concern. In the USA, approximately one-third of children aged 2–19 years are overweight or obese. This represents more than a three-fold increase in childhood obesity over the past 30 years.⁵⁴ In an analysis of perioperative complications, overweight and obese children had a higher incidence of difficult airway, upper airway obstruction, and longer postoperative recovery period.⁵⁵ Obese children are also much more likely to have obstructive sleep apnea.⁵⁶ If total body weight (TBW) is used for dose calculation, overweight children are at risk for overdose. Some authors suggest that dosing should be based upon ideal body weight (IBW) or lean body mass (LBM), although there is a lack of clear guidance in this area.^57–59 Calculating IBW and LBM in children can be relatively complicated, and validity of the measurement is lost as the child grows. Simplified weight calculations for children are expressed in the following equations:^57,59 $\begin{array}{l}\text{IBW}={\text{BMI}}_{50}\times {\text{height}}^2\\ \text{LBM}=\text{IBW}+0.29(\text{TBM}-\text{IBW})\end{array}$

Although this provides some guidance in dosing overweight children, in many circumstances calculation of appropriate dosing using this method may not be practical. It should also be remembered that when a child’s actual weight is less than IBW or LBM, the lower figure should be used. An alternative nomographic method has recently been described for use in children aged 5 years and older.⁶⁰ A nomograph is constructed by placing scales for known variables (ie, age, height, TBW) side by side. Known values are then plotted on each scale. The value of an unknown variable (LBM) is determined by the drawing a straight line from the points plotted on each scale. The point where the lines intersect the unknown variable scale is an approximation of its value (Figure 4). This method allows clinicians to quickly calculate LBM using a chart. One needs only to know the child’s age, height, and TBW. While still an ongoing area of study, researchers anticipate development of nomographic charts that are validated for children under age 5 years and incorporation of the tool into a smartphone application.

Figure 4 A novel body mass nomogram used for calculating lean body mass in children.

Note: Copyright © 2015. Dove Medical Press. Reproduced from Callaghan LC, Walker JD. An aid to drug dosing safety in obese children: development of a new nomogram and comparison with existing methods for estimation of ideal body weight and lean body mass. Anaesthesia. 2015;70:176–182.⁶⁰

Following the sedation appointment, uniform discharge criteria ensure that the child is not sent home before she or he is ready to leave direct medical supervision. A number of studies have suggested that children who are sedated for dental care routinely experience prolonged sleepiness and difficulty waking, including sleeping in the car while riding home after treatment.^61,62 While tiredness can be expected following the sedation appointment, implementation of discharge criteria helps to ensure that the child is not excessively sedated when they leave the dental office. If a child is able to achieve a University of Michigan Sedation Scale score of 0 or 1 (0, awake and alert or minimally sedated; 1, tired/sleepy, appropriate response to verbal conversation and/or sound) and able to stay awake for 20 minutes when undisturbed (the Modified Maintenance of Wakefulness Test), she or he is generally considered to be ready to return home with parental supervision.^63,64

Simulation training is increasingly being recognized as an important mechanism for improving health care quality and safety. Basic simulation can be as simple as regularly practicing emergency skills with office staff. Advanced simulation programs provide a means of practicing low frequency events using high-fidelity clinical environments and mannequins that accurately reproduce physiologic conditions (Figure 5). When simulation is incorporated into education it increases knowledge, clinical skills, and judgment more than lecture-only teaching.^65,66 Simulation is also thought to be a reliable method of teaching non-emergency sedation skills, such as presedation assessment, and it is becoming an increasingly common adjunct to sedation education programs.⁶⁷

Figure 5 High fidelity mannequin in a state-of-the-art simulation facility.

Note: Courtesy of the University of Washington Institute for Simulation and Interprofessional Studies.

Anesthesia neurotoxicity

In recent years, it has been suggested that medications used in sedation and anesthesia may have adverse effects on the developing brain.^68–70 Initial research demonstrated harm to the brains of young animals.^71–74 This raised concern that young children might also be at risk when exposed to anesthetic agents.⁷⁵ Following the publication of these concerning findings, human studies were initiated.^76–79 The results have often revealed conflicting conclusions, with some showing long-term deficits in learning and behavior while others have not.⁸⁰ This is a difficult area of study, because children who receive sedation and anesthesia commonly have pathologic conditions for which they require surgery. They may therefore be fundamentally distinct from their healthy peers. Adverse neurologic outcomes are also difficult to recognize and measure. Investigation into these findings continues, and poses a significant challenge to resources and study design. While it will likely be many years before we are able to determine the neurologic effects of sedation and anesthesia drugs with confidence, this is an area that providers must be familiar with. We do not definitively know the long-term effects of these drugs, so we must exercise judgment in recommending these services to pediatric patients. Parents should be informed of procedural risks and benefits, and sedation must only be employed when a significant benefit to the patient can be expected.

Increasing sedation success

A number of sedation rating scales have been used to evaluate sedation quality and child behavior. According to a recent review of the pediatric dental sedation literature, the Houpt Behavior Rating Scale (HBRS) has been used most frequently in research.⁸¹ The advantage of the HBRS is that it allows for evaluation of sedation depth, the child’s behavior, and an overall rating of the visit (Table 1). One disadvantage of this rating system is that the measure of success focuses primarily on the clinician’s ability to complete treatment. While clearly central to the HBRS, this characteristic is found in many other common sedation scales, including the Frankl, Ramsay, and Ohio State University Behavior Rating Scale.^82–85 A number of authors have suggested that outcome assessment should be more patient-focused. This recognizes that the intent of sedation is not only to complete a procedure with minimal movement and crying, but also that the child leaves with a positive impression of dental care.^81,86

Table 1 Houpt Behavior Rating Scale

Alertness	Crying	Movement	Overall
Asleep	No crying	No movement	Excellent: no crying or movement
Drowsy, disoriented	Intermittent or mild crying	Controllable, not interfering with treatment	Very good: some limited crying or movement
Fully awake, alert	Continuous or strong crying	Continuous, making treatment difficult	Good: difficult, but all treatment was performed
	Hysterical crying	Violent, interrupting movement	Fair: treatment interrupted, but eventually completed Poor: treatment interrupted, only partial treatment was completed Aborted: no treatment rendered

When considering lighter sedation techniques, case selection becomes increasingly important.⁸⁷ Child temperament or “behavioral style” is one factor associated with success in procedural sedation. Temperament has been defined as “[…] constitutional differences in reactivity and regulation […] influenced over time by heredity, maturation, and experience”.⁸⁸ Since the 1950s, a number of instruments have been used to evaluate child temperament. While measures vary in the literature, research has elucidated the type of child temperament associated with positive sedation outcomes. Characteristics such as emotionality, impulsivity, inflexibility, shyness, and difficulty dealing with new situations appear to be associated with sedation failure.^89–91 Conversely, adaptability, persistence, and the ability to self-regulate may be associated with increased likelihood of success.^92,93 Therefore, when considering a child for sedation, pay close attention to the behavior of the child during the consultation visit. Children who are shy, cling to parents, have difficulty tolerating simple tasks (such as dental prophylaxis or radiographs), and are unwilling to interact with the clinician may be better suited for alternative methods of behavior guidance, including general anesthesia or delayed treatment.

Children who receive mild to moderate sedation are expected to be awake and responsive to direction from the treating dentist. Therefore, it is imperative that clinicians employ their best non-pharmacologic behavior management skills with sedated patients.¹³ While these skills are generally regarded as a core competency of pediatric dentistry, they are increasingly being recognized as important in the medical literature as well.^94–98 Interventions such as distraction have been shown to decrease anxiety and pain perception in non-sedated patients.⁹⁹ When effectively incorporated into the sedation scheme, a combined pharmacologic and non-pharmacologic technique was also more effective at reducing child distress than pharmacologic techniques alone.¹⁰⁰ Non-pharmacologic methods may be particularly effective for sedated young children with active imaginations. Also, because adequate sedation requires both anxiety reduction and pain control, excellent local anesthesia is critical. A child with profound analgesia is much more likely to be in a state of mind that facilitates good sedation.

Increasing role of dental anesthesia

Today’s sedation practitioner faces significant challenges to achieve the described levels of child-centered care. Reports indicate that while child behavior in the dental office is becoming more difficult, parents are becoming increasingly particular about their child’s experience.^8,101,102 At the same time, concerns about child safety during sedation procedures have drawn scrutiny of sedation performed by dental practitioners in the office setting. The use of general anesthesia for pediatric dental treatment has grown accordingly. Surveys indicate that over the past 30 years parents have become much more accepting of general anesthesia for dental treatment.¹⁰³ This may be due to the public’s familiarity with anesthesia performed in surgery centers and other outpatient facilities. While in the past, nearly all dental surgery was provided in the hospital setting, today dentists are incorporating outpatient anesthesia services into their private offices.^102,104 With the increased availability of ambulatory anesthesia services, general anesthesia in the dental clinic has become a safe and cost-effective mechanism to deliver dental care to healthy children. Consequently, it is possible that in the future we will see a trend toward lighter in-office sedation. In turn, for larger cases and more difficult patients, general anesthesia may replace deeper sedation techniques.

Conclusion

Providing quality dental care to young children can be a challenge. Pediatric dental sedation allows the clinician to provide treatment in a way that is minimally traumatic and preserves the child’s trust. Although sedation is an effective tool to manage pediatric anxiety, adverse treatment outcomes and increased regulatory scrutiny have made this a contentious area. Therefore, practitioners should strive to reduce patient risk by carefully selecting patients who are medically optimized for sedation and instilling a culture of safety into clinical practice. Given parent preferences and high levels of pediatric dental disease, it is likely that we will see the need for sedation continue to grow in the future. This is an exciting opportunity to increase sedation success by refining behavioral selection parameters, utilizing modern drugs and routes, and employing the services of anesthesiologists in outpatient settings.

Disclosure

The authors report no conflicts of interest in this work.