The impact of pulmonary rehabilitation on severe physical inactivity in patients with chronic obstructive pulmonary disease: a pilot study

Abstract

Introduction

In patients with COPD, severe physical inactivity (SPI, which is defined as total daily energy expenditure/resting energy expenditure; physical activity level [PAL] ratio, <1.4) is associated with increased morbidity and mortality. Pulmonary rehabilitation (PR) increases physical capacity in COPD, but the impact on SPI is unknown. In this study, we aimed at elucidating the prevalence of SPI in COPD patients attending standard PR, the impact of PR on SPI prevalence, and the relationship between SPI and time spent in moderate physical activity thus whether American College of Sports Medicine (ACSM) recommendations are clinically useful in excluding SPI in COPD.

Methods

This is a prospective non-interventional pilot study on patients with COPD completing PR, consenting to wear an accelerometer (Sensewear^© Armband) for a week before and after completing PR to assess changes in energy expenditure, time spent in physical activity, and number of daily steps. Low level of daily physical activity was not an inclusion criterion.

Results

In total, 57 patients completed the study and 31 (54%) had SPI at baseline. In patients with SPI, baseline median FEV₁ was 48 (range, 28–86) % of predicted and GOLD B, n=11 (35%)/GOLD D, n=20 (65%). Surprisingly, 31 of SPI patients (97%) spent ≥150 minutes/week in moderate physical activity. After rehabilitation, 24 (78%) did not change activity level and were persistently SPI. We observed no differences at baseline between patient responding (n=7) vs not responding (n=24) to PR. Responders increased number of daily steps and time spent in lighter but not moderate physical activity during rehabilitation.

Conclusion

In this pilot study, SPI was prevalent, and PR had limited impact. Contraintui-tively, most patients with SPI complied with general recommendations of weekly hours spent in moderate physical activity. Our study highlights that increasing time spent in light activity rather than improving time spent in moderate activity is important in COPD patients with chronic dyspnea.

Keywords:

• COPD
• pulmonary rehabilitation
• severe physical inactivity
• Sensewear^©

Introduction

COPD is associated with reduced levels of daily physical activity.¹ The chronic airflow limitation results in exercise-limiting dyspnea and fatigue, and in particular, COPD patients are at risk for severe physical inactivity (SPI), which is defined as a total daily energy expenditure/resting energy expenditure ratio <1.4.^2–4 SPI is prevalent in the majority of COPD patients in GOLD group D⁵ and is highly related to both morbidity and mortality.^6–8 However, SPI assessment requires measurement of resting energy expenditure by indirect calorimetry or an accelerometer (eg, SenseWear^© Armband; BodyMedia, Pittsburgh, PA, USA) because no equation for calculated resting energy expenditure has shown acceptable accuracy in COPD.⁹ According to the American College of Sports Medicine (ACSM), healthy subjects are recommended to engage in moderate physical activity for 30 minutes a day – at least 5 days a week – to reduce the risk of chronic diseases and disabilities.¹⁰ The same recommendations are applicable for older adults according to WHO.¹¹ In COPD, it is not known whether complying with the ACSM goal precludes SPI.

Pulmonary rehabilitation (PR) is a validated intervention in COPD, and exercise is the cornerstone of the program.¹² Even though high intensity and duration of physical activity are negatively correlated to morbidity and mortality in COPD,^{2,5,6,13–15} it is not known whether the standard ACSM recommendation is a relevant success criterion for PR in COPD.^6,7,16–19 Recent research has suggested that lighter activities are more efficient in avoiding inactivity including SPI than heavier physical activities.^3,4,15,20,21

In the present study, we aimed at elucidating the prevalence of SPI in COPD patients attending standard PR, the impact of PR on the prevalence of SPI, and the relationship between SPI and time spent in moderate physical activity, thus it is unknown if the ASCM recommendations is clinically useful in excluding SPI in COPD.

Methods

Design

This prospective, observational cohort study was designed as a pilot study and conducted in 2013–2014 in PR centers at Naestved Hospital and in the communities of Naestved, Faxe, and Vordingborg centers (Region Zealand, Denmark). Patients were enrolled on the first day of the rehabilitation program (Visit 1) and had a follow-up visit in the last week of the rehabilitation course (Visit 2).

Inclusion criteria

Inclusion criteria were physician-diagnosed COPD confirmed by spirometry (GOLD classes B–D),¹² referral for PR, ability to give informed consent, no other life-threatening illnesses, no history of asthma, and no acute exacerbation within the last 4 weeks prior to inclusion.²²

Written and oral informed consent was obtained. This study was approved by the Danish National Ethical Committee and complied with the Declaration of Helsinki. The study is registered with ClinicalTrials.gov (number 34431).

Study procedures

The rehabilitation program consisted of exercise training, education in management of disease and pharmacology, nutrition, and help with smoking cessation. The duration of the program ranged from 7 to 12 weeks, 2 hours twice a week according to the guidelines from the Danish Health Authority.²³ The exercise training consisted of 1 hour of supervised training twice a week with an equal distribution between endurance and resistance training.²³ Spirometry (MicroLoop^© spirometer; Becton, Dickinson and Company, Franklin Lakes, NJ, USA) measurement was performed at both visits according to the guidelines of the American Thoracic Society (ATS) and the European Respiratory Society (ERS).²⁴ Patient-reported outcome measures were obtained at both visits. Background data were obtained at Visit 1: gender, weight, height, and exacerbations (acute exacerbation in COPD [AECOPD]) comorbidities and medication.

Primary and secondary outcomes

Primary outcome

The primary outcome of this study was the prevalence of SPI before and after PR.

Secondary outcomes

The secondary outcome of this study was minutes spent in light respective moderate physical activity, number of patients spending ≥150 minutes/week in light (≥2 Metabolic Equivalent of Task [MET]) respective moderate (≥3 MET) physical activity, number of daily steps, and patient-reported outcome measures (COPD assessment test [CAT] and mMRC) before and after PR.

Physical activity assessment

Subjects were instructed to wear an activity monitor (SenseWear Armband) continuously for 7 days after each study visit. The use of SenseWear in patients with COPD has previously been validated.^29,30 According to the manufacturer’s recommendation, the activity monitor is worn on the back of the upper right arm at the level of the triceps. This monitor assesses acceleration in two planes by using a bi-axial accelerometer which measures and stores skin temperature, near body temperature, heat flux and galvanic skin resistance. Activity is estimated in MET, a measure of energy expenditure (1 MET=1 kcal/kg/h). Output from the SenseWear includes the following:

• Total energy expenditure (TEE): number of calories burnt every day.

• Resting metabolic rate (RMR): the rate at which the body burns energy when it is at complete rest.

• Physical activity level (PAL): TEE divided by the RMR. • Minutes spent at light (≥2 MET) and moderate (≥3 MET) physical activity.

• Daily number of steps.

Data from patients wearing the monitor >2 days and >90% of daily use were included.²⁵

Patient-reported outcome measures

CAT consisted of a self-reported, well-validated 5-point Likert scale, eight-item questionnaire with four respiratory items and four general health items (score range, 0–40).²⁶ mMRC scale consisted of a self-reported, well-validated, 5-point Likert scale, one-item questionnaire (score range, 0–4). A score ≥2 is considered “severe dyspnea” and is an inclusion criterion for PR in Denmark.^12,18

Statistical analyses

Statistical analyses were performed using STATA 14.1. Missing data were omitted from analyses.

Continuous data are presented as a median (range) and categorical data as incidence (%). Differences were assessed using the chi-squared test or Wilcoxon signed-rank test. Statistical significance was set at P<0.05.

Results

Patients

Between January 15, 2013, and February 10, 2014, 163 patients were consecutively screened, and 67 patients were included (Figure 1). Totally, 57 patients completed the trial (community-based rehabilitation: n=43, 75%; hospital-based rehabilitation: n=14, 25%) and were included in the analysis (female: 53%; age, 68 years [range, 50–80 years]). Baseline median FEV₁ was 50 (range, 22–96) % of predicted, and patients were divided between GOLD class B (n=28) respective D (n=29). Median body mass index (BMI) was 27 kg/m² (range, 17–51 kg/m²), and median self-reported number of moderate to severe AECOPD in preceding 12 months was 1 (0–7; Table 1). Patients completing the study and patients dropping out did not differ significantly in baseline characteristics. Eight of the patients (14%) had missing SenseWear data at either baseline or follow-up. Table 2 shows that 74% complied with the ASCM’s recommendation for physical activity at baseline and that PR increased time spent in light but not moderate physical activity. Nine patients (16%) used a walker, and they did not differ significantly regarding daily steps or minutes/week spent in ≥3 MET as opposed to patients not using walking aids. We registered the following comorbidities: 1) ischemic heart disease, n=3 (5%); 2) heart failure, n=12 (21%); 3) osteoporosis, n=5 (9%); 4) arthritis or joint pain, n=32 (56%); 5) anxiety, n=18 (32%); 6) depression, n=9 (16%); 7) stroke or other neurologic disease, n=5 (9%); and 8) diabetes, n=4 (7%).

Table 1 Group characteristics (n=57)

	Visit 1
Age (years), median (range)	68 (50–80)
Female gender, n (%)	30 (53)
BMI, median (range)	27 (17–51)
FEV1 (% predicted), median (range)	50 (22–96)
GOLD, n (%)
A	0 (0)
B	28 (49)
C	0 (0)
D	29 (51)
Community/hospital, n (%)	43 (75)/14 (25)
CAT, median (range)	17 (4–32)
mMRC, median (range)	2 (1–4)
AECOPD in the recent year, median (range)	1 (0–7)

Abbreviations: AECOPD, acute exacerbation in COPD; BMI, body mass index; CAT, COPD Assessment Test.

Table 2 Impact of pulmonary rehabilitation on time spent in physical activity and number of patients being active for ≥150 minutes/ week measured using activity monitor (SenseWear^©) during 1 week

	All participants (n=57)		SPI at baseline (n=31)
	Baseline	Follow-up	Baseline	Follow-up
Hours/week at ≥3.0 MET (moderate physical activity), median (range)	6.0 (0–59)	7.7 (0.1–32)	4.4 (0.2–21)	4.8 (0.1–14)
Patients with ≥3.0 MET (moderate physical activity) in ≥150 minutes/week, n (%)	39 (74)	42 (79)	21 (69)	22 (76)
Hours/week at ≥2.0 MET (light physical activity), median (range)	18.8 (0.8–61)	21.5 (1.9–59)a	9.9 (0.8–39)	16.8 (1.9–31)
Patients with ≥2.0 MET (light physical activity) in ≥150 minutes/week, n (%)	50 (94)	52 (98)	31 (97)	28 (97)

Note:

a P<0.05, intragroup difference between time points.

Abbreviations: MET, Metabolic Equivalent of Task; SPI, severe physical inactivity.

Figure 1 Flowchart of patients included in the study.

Abbreviation: AECOPD, acute exacerbation in COPD; SPI, severe physical inactivity.

Patients with SPI at baseline

Totally, 31 (54%) patients had SPI at baseline, yet 96% of patients with baseline SPI spent ≥150 minutes/week in moderate physical activity (≥3 MET), thus complying with ASCM recommendation for the general population (Table 2). Only seven patients (22%) responded to PR by increasing PAL to ≥1.4 (“responders”; Table 2). Responders significantly improved number of daily steps and time spent in lighter but not moderate physical activity compared to patients with persistent SPI. Analyzing differences between responders and patients with persistent SPI revealed no significant baseline differences (Table 3).

Table 3 Subgroup analyses of patients with SPI at baseline (n=31): differences at baseline and follow-up between patients remaining severely inactive (SPI) and patients not being severely inactive (non-SPI) at follow-up (responders)

	Persistent SPI (n=24)		Responders (n=7)
	Baseline	Follow-up	Baseline	Follow-up
Physical activity level (TEE divided by RMR), median (range)	1.3 (1.2–1.3)	1.3 (1.1–1.3)a	1.3 (1.1–1.3)b	1.4 (1.4–1.5)a,b
Resting energy expenditure (J/day)	6,552 (4,464–9,768)	6,969 (4,344–8,784)	6,432 (4,872–9,768)	7,032 (4,728–10,920)
Steps, median (range)	1,758 (226–5,501)	1,683 (180–5,065)a	3,149 (112–4,755)	4,015 (1,598–5,564)a
Minutes/week at ≥3 MET, median (range)	264 (12–1,098)	276 (6–810)	348 (48–1,284)	546 (138–1,704)
No of patients with ≥3 MET in 150 minutes/week, n (%)	15 (60)	18 (75)	5 (71)	6 (86)
Minutes/week in ≥2 MET, median (range)	552 (48–2,160)	960 (114–1,860)a	1,164 (252–2,340)	1,608 (1,200–2,520)a
No of patients with ≥2 MET in 150 minutes/week, n (%)	22 (92)	23 (96)	7 (100)	7 (100)
CAT, median (range)	17 (10–32)	16 (7–29)	17 (11–28)	19 (11–34)
mMRC, median (range)	2 (1–4)	2 (0–4)	2 (1–4)	2 (1–4)
BMI, median (range)	27.9 (18.4–42.9)		27.0 (16.6–27.8)
FEV1 (% predicted), median (range)	48 (28–73)		54 (26–96)
COPD class B, n (%)	9 (38)		2 (29)

Notes:

a Intergroup difference, P<0.05.

b Intragroup difference, P<0.05. Gray box, only baseline data available.

Abbreviations: BMI, body mass index; CAT, COPD Assessment Test; MET, Metabolic Equivalent of Task; RMR, resting metabolic rate; SPI, severe physical inactivity; TEE, total energy expenditure.

Discussion

This pilot study showed that SPI is prevalent in patients referred for PR and that rehabilitation improved objectively measured physical activity in a minority of these patients. To our knowledge, this is the first study to address these issues.

It is well established that self-reported level of physical activity is poorly associated with objectively measured physical activity.²⁷ Surprisingly, we found that 96% of patients with SPI spent ≥150 minutes/week in objectively measured moderate physical activity. Thus, the general recommendations for physical activity by ACSM¹⁰ seem not to be clinically meaningful in COPD patients with chronic dyspnea (mMRC, ≥2). Our data support that increasing lighter rather than moderate or hard physical activity is more efficient in reducing sedentary lifestyle.^3,4,16,20,21 However, the paradoxical finding of sedentary lifestyle (SPI) and sufficient amounts of moderate physical activity might have other explanations. As SPI is defined as a low ratio between total daily energy expenditure and resting energy expenditure, SPI might be a result of low total daily energy expenditure and/or increased resting energy expenditure. Several studies have found that moderate to severe COPD is associated with increased resting energy expenditure, lower fat-free body mass, and increased protein turnover.^4,5,28 In addition, more profound structural and metabolic changes in peripheral and respiratory muscles seen in COPD patients result in increased energy expenditure (kcal/kg/h=MET) at lower levels of exercise.²⁹ This is even more pronounced with low BMI, as energy expenditure is weight dependent; however, Kao et al²⁸ found that low fat-free mass but not low BMI was associated with increased energy expenditure. We found no differences in baseline BMI in responders vs patients with persistent SPI (Table 2), but did not include measurements of fat-free mass. We found no differences in resting energy expenditure between responders and patients with persistent SPI, but the statistical power was low due to the limited sample size; thus, we cannot rule out that COPD patients with SPI benefiting from PR is a distinct subgroup.

The PAL and time spent in moderate physical activity are two different ways to measure physical activity, and both are important predictors of morbidity and mortality.^6–8,10 Although the impact of PR on quality of life (QoL), exercise capacity, and dyspnea is well established, less evidence exists on the impact on time spent in moderate daily physical activity, although some studies have focused on daily steps and walking speed.^22,30–37

Limitations

There are several limitations in this study, which needs consideration. First, the present study is a pilot study and thus vastly underpowered to draw solid conclusion on statistically insignificant findings. However, this observational study included COPD patients admitted daily for PR and was not preselected according to self-reported or measured levels of physical activity. Second, PR was delivered at four sites with different duration despite involving mandatory elements of training and education twice a week according to the Danish guidelines.²³ Our data sample was too small to adjust for this heterogeneity. Yet, the recommended duration of PR varies among guidelines (4–12 weeks American Association of Cardiovascular and PR; ≥8 weeks ATS/ERS; not specified by ASCM), whereas these guidelines agree on sessions at least three times weekly.³⁸ Thus, we might have observed a smaller impact of rehabilitation by following the Danish guidelines. It will be interesting to ascertain SPI prevalence as well as impact of rehabilitation in larger centers with more prevalent sessions.

Third, the accelerometer used (SenseWear) has – despite being well validated in COPD³⁹ – several limitations. It is worn on the upper right arm and is not usable in water. Thus, measurements of energy expenditure during swimming or activities with fixed arms (eg, cycling, walking aids) are absent or underestimated. In our cohort, a minority used a walker. Furthermore, to ensure representative activity data, we excluded data if SenseWear was worn for <48 hours or if on-body time was <90%. In addition to the challenge of recollecting physical activity, Pitta et al⁴⁰ reported adherence difficulties on using an accelerometer in 19% of COPD subjects including body placement and technical issues, such as battery problems. In our study, the missing SenseWear data were 14% both due to exclusion criteria as mentioned above and complete lack of obtained data. Little is known about the day-to-day variations in objectively measured physical activity in moderate to severe COPD patients, but it is considerable in healthy adults.⁴¹ It has been documented that PALs increase during the week wearing an accelerometer, probably due to the novelty-induced increased awareness of healthy living.^41,42 Fourth, we did not adjust for comorbidities such as osteoporosis, low back pain, diabetes, poor nutrition, cognitive dysfunction, heart disease, rheumatoid diseases, anxiety, or depression, which are all independently associated with decreased physical activity.^{38,40,43–46} Even though comorbidities are present in 70% of COPD patients and known to interfere with the outcome of PR, an improvement is still seen.^47,48 However, the impact of exercise training provided during rehabilitation is not COPD specific, and all patients volunteered to participate in the rehabilitation program and the study. This selection probably selected the patients most eager to improve their levels of physical activity.

Conclusion

Our present pilot study suggests that objectively measured SPI is common in patients referred for PR, which only improves daily physical activity in a minority of subjects despite wearing an accelerometer in a clinical trial. SPI at baseline was not precluded by being moderately physically active for ≥150 minutes/week. As SPI is significantly associated with morbidity and mortality, future studies should address SPI-focused intervention strategies and elucidate factors associated with failure to improve physical activity in COPD patients receiving PR.

Acknowledgments

The study was supported by the Research Unit at Naestved Hospital and through a one-year scholarship from Southern University of Denmark. Financial contributions to equipment and laboratory testing were provided by Maersk Foundation, Meyers scholarship, and the local Research Foundation at Naestved Hospital.

Disclosure

The authors report no conflicts of interest in this work.