Future prospects of transplantation therapy for neurological diseases using adult bone marrow stromal cells

Abstract

Bone marrow stromal cells (BMSCs) can differentiate into neuronal cell types as well as mesenchymal cell types. BMSCs possess three distinctive abilities: secretion of neurotrophic factors; differentiation into neurons, glia and Schwann cells; and migration throughout the CNS. Extensive preclinical studies of BMSC transplantation therapy have investigated the treatment of various neurological disorders. This review provides a concise overview of the mainly preclinical studies of transplantation therapy based on BMSCs derived from adult bone marrow. This highlights the three main characteristics that provide the potential for the treatment of neurological disorders.

Keywords::

• bone marrow stromal cell
• neural stem cell
• neurological disorder
• regenerative medicine
• transplantation