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Clinical Lipidology Volume 6, 2011 - Issue 1
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Caveolae and lipid trafficking in adipocytes

Paul PilchDepartment of Biochemistry, Boston University School of Medicine,, 715 Albany St, Boston, MA 02118, USA;Department of Medicine, Boston University School of Medicine, MA, USA, Tel.: +39 755 7501 5835, E-mail: [email protected]Correspondence[email protected]
,
Tova MeshulamDepartment of Biochemistry, Boston University School of Medicine,, 715 Albany St, Boston, MA 02118, USA
,
Shiying DingDepartment of Biochemistry, Boston University School of Medicine,, 715 Albany St, Boston, MA 02118, USA
&
Libin LiuDepartment of Biochemistry, Boston University School of Medicine,, 715 Albany St, Boston, MA 02118, USA;Department of Medicine, Boston University School of Medicine, MA, USA, Tel.: +39 755 7501 5835, E-mail: [email protected]
Pages 49-58 | Published online: 18 Jan 2017
 
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Abstract

The abundance of caveolae in adipocytes suggests a possible cell-specific role for these structures, and because these cells take up and release fatty acids as their quantitatively mostrobust activity, modulation of fatty acid movement is one such role that is supported by substantial in vitro and in vivo data. In addition, caveolae are particularly rich in cholesterol and sphingolipids, and indeed, fat cells harbor more cholesterol than any other tissue.In this article, we review the role of adipocyte caveolae with regard to these important lipid classes.

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