Antimicrobial susceptibility Patterns of Bacteria that Commonly Cause Bacteremia at a Tertiary Hospital in Zambia

Abstract

Background: Bloodstream infections and antimicrobial resistance cause global increases in morbidity and mortality. Aim: We evaluated the antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia in humans. Materials & methods: We conducted a retrospective cross-sectional study at the University Teaching Hospitals in Lusaka, Zambia, using Laboratory Information Systems. Results: The commonest isolated bacteria associated with sepsis were Klebsiella pneumoniae. The distribution of bacteria associated with bacteremia in different wards and departments at University Teaching Hospitals was statistically significant (χ2 = 1211.518; p < 0.001). Conclusion:K. pneumoniae, Escherichia coli, Pantoea agglomerans and Enterococcus species have developed high resistance levels against ampicillin, cefotaxime, ciprofloxacin, gentamicin and trimethoprim/sulfamethoxazole and a very low resistance levels against imipenem and Amikacin.

Keywords::

• antimicrobial resistance
• antimicrobial susceptibility patterns
• bacteremia
• bloodstream infections

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fmb-2020-0250

Author contributions

M Kasanga and J Wu conceived and designed the study. M Chileshe, S Mudenda and M Kasanga did the literature search. M Kasanga, BB Solochi, AL Shibemba, T Kantenga, M Siyanga, M Chileshe, MJ Mwiikisa, T Gondwe and R Nakazwe acquired the data. M Kasanga, M Chitalu and J Wu analyzed and interpreted the data. M Kasanga and J Wu drafted the initial manuscript. J Wu, S Mudenda, M kasanga and M Chileshe critically revised subsequent drafts of the paper. All authors read, edited and approved the final version of the manuscript.

Financial & competing interests disclosure

Funding for publication services were provided by the Zhengzhou University 2020 Key Project of Discipline Construction (XKZDQY202007); Henan Medical Education Research Project (Wjlx2018008); Zhengzhou University 2020 Educational Reform Research and Practice Project (2020zzuJXLX003). J Wu obtained the funding for this study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The study was approved by the University of Zambia Biomedical Ethics Committee (UNZABREC), federal assurance #: 00000338, protocol #: 975-2020.

Additional information

Funding

Funding for publication services were provided by the Zhengzhou University 2020 Key Project of Discipline Construction (XKZDQY202007); Henan Medical Education Research Project (Wjlx2018008); Zhengzhou University 2020 Educational Reform Research and Practice Project (2020zzuJXLX003). J Wu obtained the funding for this study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.