Cyclodextrin Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review

Abstract

Aim: The study aimed to review experimental models using cyclodextrins to improve antibacterial drugs’ physicochemical characteristics and biological activities. Methods: The following terms and their combinations were used: cyclodextrins and antibacterial agents in title or abstract, and the total study search was conducted over a period up to October 2022. The review was carried out using PubMed, Scopus and Embase databases. A total of 1580 studies were identified, of which 27 articles were selected for discussion in this review. Results: The biological results revealed that the antibacterial effect of the inclusion complexes was extensively improved. Cyclodextrins can enhance the therapeutic effects of antibiotics already existing on the market, natural products and synthetic molecules. Conclusion: Overall, CDs as drug-delivery vehicles have been shown to improve antibiotics solubility, stability, and bioavailability, leading to enhanced antibacterial activity.

Plain language summary

The overuse of drugs can cause bacteria to become less susceptible to them. This is known as resistance. One idea on how to tackle this resistance is by using cyclodextrins (CDs). CDs can change how drugs work, making them better at fighting bacteria. As CDs are already used in making drugs, they are a good choice for the basis of creating new drugs.

Tweetable abstract

Cyclodextrins play a crucial role in enhancing the physical and chemical characteristics of drugs, leading to improved bioavailability, biodistribution and solubility.

Graphical abstract

Cyclodextrin inclusion complexes and their use as new antibacterial therapeutic alternatives.

Keywords::

• antibacterial agents
• antibiotics
• cyclodextrins
• inclusion complex
• technology
• treatments

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fmb-2023-0124

Author contributions

All authors contributed to the study conception and design. Material preparation, data collection and data analysis were performed by AM Santos, JAC Nascimento, and SVS Cézar. The first draft of the manuscript was written by AM Santos, JAC Nascimento and SVS Cézar, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Acknowledgments

The authors dedicate this article to the entire scientific community that fights for quality science.

Financial disclosure

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors thank CAPES and FAPITEC/SE for their financial support. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors thank CAPES and FAPITEC/SE for their financial support. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.