Novel Approaches to Imaging Epilepsy by MRI

Abstract

As the concept of a network of injury has emerged in the treatment of epilepsy, the importance of evaluating that network noninvasively has also grown. Recently, studies utilizing magnetic resonance spectroscopic imaging, manganeseenhanced MRI and functional (f)MRI measures of resting state connectivity have demonstrated their ability to detect injury and dysfunction in cerebral networks involved in the propagation of seizures. The ability to noninvasively detect neuronal injury and dysfunction throughout cerebral networks should improve surgical planning, provide guidance for placement of devices that target network propagation and provide insights into the mechanisms of recurrence following resective surgery.

Keywords:

• epilepsy
• magnetic resonance spectroscopic imaging
• manganese-enhanced MRI
• neuronal networks
• resting state connectivity

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.