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Abstract
Evaluation of: Ozawa D, Yagi H, Ban T et al.: Destruction of amyloid fibrils of a β2-microglobulin fragment by laser beam irradiation. J. Biol. Chem. 284(2), 1009–1017 (2009). In this study, the authors discovered that laser beam irradiation with thioflavin T could stop the extension of β2-microglobulin fibrils and even degrade preformed amyloid fibrils. These reactions require both thioflavin T and a laser beam at 442 nm; active oxygen plays an important role. This approach may be a new therapeutic strategy for destroying fibrils in dialysis-related amyloidosis as well as other types of amyloidosis or related disorders, including Alzheimer‘s disease, familial amyloid polyneuropathy, Parkinson‘s disease and Huntington‘s disease.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript