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Abstract
Lasmiditan is a new neurally acting antimigraine drug that acts as a highly selective serotonin1F receptor agonist. Its chemical structure is distinctly different from that of triptans. Its dose-dependent clinical efficacy was proven in two clinical Phase II trials using intravenous and oral formulations. Oral lasmiditan showed significant headache relief after 2 h at doses of 50, 100, 200 and 400 mg. Adverse events of lasmiditan were dose-dependent and mainly associated with the CNS. They predominantly included dizziness, paresthesia and fatigue, and were mostly mild-to-moderate in intensity. Preclinical studies showed that, unlike triptans, lasmiditan lacks any vasoconstrictive activity, which makes it a promising drug for patients with contraindications to triptans owing to cardio- or cerebro-vascular diseases, or an elevated vascular risk profile.
Financial & competing interests disclosure
U Reuter has received a honoraria for participation in advisory board meetings of CO-Lucid. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.