Tumor Blood Perfusion-Based Requirement of Nanoparticle Dose-Loadings for Plasmonic Photothermal Therapy

Abstract

Aim: Blood perfusion-based requirement of nanoparticle dose-loadings is computed for plasmonic photothermal therapy of a tumor. Methods: Thermal damage is quantified through coupled multiphysics approach to specify nanoparticle loadings. Results: For low blood perfusion, the nanoparticle loading of 1 mm at 0.02 mg/ml or 3 mm at 0.2 mg/ml concentration may be chosen depending upon the desired tumor margins. For high blood perfusion, nanoparticle loading of 3 mm at 0.2 mg/ml concentration with irradiation parameters of 1 W/cm² and 200 s seems desirable. Conclusion: Lower nanoparticle loadings within deeper periphery of tumor damage the deeper healthy tissue. If tumor margin is not to be ablated, then higher nanoparticle loadings should be opted instead of higher irradiation duration.

Keywords:

• blood perfusion
• cancer
• gold nanoparticles
• plasmonic photothermal therapy
• therapeutics

Financial & competing interests disclosure

This work was supported by the Department of Biotechnology, Govt of India (Research Grant no. BT/PR20221/NNT/28/1050/2016) under nanobiotechnology program. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.