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Research Article

Magnetic Nanomedicine for CD133-Expressing Cancer Therapy Using Locoregional Hyperthermia Combined with Chemotherapy

ORCID Icon, , , , & ORCID Icon
Pages 2543-2561 | Received 26 May 2020, Accepted 01 Sep 2020, Published online: 26 Oct 2020
 

Abstract

Aim: Cells with CD133 overexpression, a theoretical cancer stem cells (CSCs) marker, have been shown to induce colorectal cancer (CRC) initiation and relapse. Therefore, the detection and treatment of CSCs are the most important factors in overcoming CRC. Materials & methods: Herein, we developed a magnetite-based nanomedicine (superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticle) using loco-regional hyperthermia combined with chemotherapy for CRC- and CSC-specific targeting treatment. Results: The designed nanoparticles were highly biocompatible and exhibited a higher temperature increase rate under radiofrequency generator irradiation. The nanoparticles could be used as a T2-weighted magnetic resonance imaging contrast media, and also applied during hyperthermia and chemotherapy to display a synergistic anticancer effect. Conclusion: Therefore, the superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticles are a powerful candidate for future antitumor strategies.

Author contributions

SJ Yang and SY Tseng contributed equally to this work. SJ Yang, KC Chen and MJ Shieh conceived the idea and supervised this work. SJ Yang, SY Tseng and CH Wang synthesized the nanoparticles and performed the characterization of nanoparticles. TH Young designed the graphical abstract and scheme image. The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.

Financial & competing interests disclosure

The authors appreciate the help from the National Taiwan University College of Medicine and the National Taiwan University Hospital. This work was supported by the Ministry of Science and Technology (MOST 106-2314-B-002 -015 -MY3 and 106-3114-E-002-004-). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.

Additional information

Funding

The authors appreciate the help from the National Taiwan University College of Medicine and the National Taiwan University Hospital. This work was supported by the Ministry of Science and Technology (MOST 106-2314-B-002 -015 -MY3 and 106-3114-E-002-004-). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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