Polymeric Micelles Loaded In Situ Gel with Prednisolone Acetate for Ocular Inflammation: Development and Evaluation

Abstract

Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

Keywords::

• entrapment efficiency
• ophthalmicpolymeric micelles
• transcorneal permeation
• uveitis

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/nnm-2023-0123

Financial & competing interests disclosure

This research work was funded by Institutional Fund Projects under grant no. (IFPIP: 1527-130-1443). The authors gratefully acknowledge technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The experimental protocol was approved by the Institutional Animal Ethics Committee (MMCP-IAEC-20), India.

Additional information

Funding

This research work was funded by Institutional Fund Projects under grant no. (IFPIP: 1527-130-1443). The authors gratefully acknowledge technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.