Biphasic Magnetic Nanoparticles–Nanovesicle Hybrids for Chemotherapy and Self-Controlled Hyperthermia

Abstract

Aim: The aim was to develop magnetic nanovesicles for chemotherapy and self-controlled hyperthermia that prevent overheating of tissues. Materials & methods: Magnetic nanovesicles containing paclitaxel and a dextran-coated biphasic suspension of La_0.75Sr_0.25MnO₃ and Fe₃O₄ nanoparticles (magnetic nanoparticles) were developed. Results: Encapsulation efficiencies of magnetic nanoparticles and paclitaxel were 67 ± 5 and 83 ± 3%, respectively. Sequential release performed at 37°C for 1 h followed by 44°C for another 1 h (as expected for intratumoral injection), showed a cumulative release of 6.6% (109.6 µg), which was above the IC₅₀ of the drug. In an alternating current magnetic field, the temperature remained controlled at 44°C and a synergistic cytotoxicity of paclitaxel and hyperthermia was observed in MCF-7 cells. Conclusion: Magnetic nanovesicles containing biphasic suspensions La_0.75Sr_0.25MnO₃ and Fe₃O₄ nanoparticles encapsulating paclitaxel have potential for combined self-controlled hyperthermia and chemotherapy.

Keywords::

• biphasic suspension
• cancer
• chemotherapy
• magnetic nanovesicle
• self-controlled hyperthermia

Financial & competing interests disclosure

The financial support provided by the Department of Information Technology and the Nanomission, Department of Science and Technology are gratefully acknowledged. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all animal experimental investigations.

Acknowledgements

The authors thank the Centre for Research in Nanotechnology and Nanoscience for using their instrumentation facilities.

Additional information

Funding

The financial support provided by the Department of Information Technology and the Nanomission, Department of Science and Technology are gratefully acknowledged. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.