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Abstract
1. Prothioconazole (PTC) is a new type of triazolinthione fungicide used worldwide. Despite its widespread use, the basic toxicokinetics (TK) information for health risk assessments of PTC is limited.
2. TK behavior and metabolism studies of PTC were performed in male adult Sprague Dawley (SD) rats after a single oral administration. Serial blood and tissue samples were analyzed for their PTC content by high-performance liquid chromatography (HPLC) to obtain comprehensive time-course data for estimation of TK parameters.
3. PTC was rapidly but incompletely absorbed from the gastrointestinal tract of fasted adult rats. It was widely distributed in all parts of body, but demonstrated little tendency to accumulate. And PTC was excreted mainly in the form of parent compound.
4. The detection of PTC in brain and testis proved that further investigations are required to determine whether PTC could result in neurotoxicity and male reproductive toxicity.
Acknowledgements
We thank Li Feng and Xiaoqi Pan for their kind technical assistance
Declaration of interest
The authors declare no conflicts of interest.