Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 12
60
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver

, , , &
Pages 1345-1352 | Received 13 Aug 1993, Published online: 22 Sep 2008

References

  • Afanas'ev I. B., Dorozhko A. I., Brodskii A. V., Kostyuk V. A., Potapovitch A. I. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochemical Pharmacology 1989; 38: 1763–1769
  • Ballet F. Hepatic circulation: potential for therapeutic intervention. Pharmaceutical Therapeutics 1990; 47: 281–328
  • Barrow A., Griffiths L. A. Metabolism of the hydroxyethylrutosides. III. The fate of orally administered hydroxyethylrutosides in laboratory animals; metabolism by rat intestinal microflora. in vitro. Xenobiotica 1974; 4: 743–754
  • Bartosek I., Guaitani A., Garattini S. Long-term perfusion of isolated rat liver. Pharmacology 1972; 8: 244–258
  • Berqvist D., Hallbrook T., Lindblad B., Lindhagen A. A double-blind trial of O-(β-hydroxy ethyl)-rutosides in patients with chronic venous insufficiency. Vasa 1981; 10: 253–260
  • Bortolotti A., Corada M., Barzago M. M., Celardo A., Guaitani A., Bonati M. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches. Drug Metabolism and Disposition 1991; 19: 430–435
  • Cova D., De Angelis L., Giavarini F., Palladini G., Perego R. Pharmacokinetics and metabolism of oral diosmin in healthy volunteers. International Journal of Clinical Pharmacology, Therapy and Toxicology 1992; 30: 29–33
  • Damon P., Flandre O., Michael F., Perdrix L., Labrid C., Crastes De Paulet A. Effect of chronic treatment with a purified flavonoid fraction on inflammatory granuloma in the rat. Study of prostaglandin E2 and F2α and thromboxane B2 release and histological changes. Arzneimittel-Forschung 1987; 37: 1149–1153
  • Garattini S., Guaitani A., Bartosek I. Use of isolated perfused liver in the study of drug metabolism. Isolated Liver Perfusion and its Applications, I. Bartosek, A. Guaitani, L. L. Miller. Raven, New York 1973; 225–234
  • Gott D. M., Griffiths L. A. Effects of antibiotic pretreatments on the metabolism and excretion of [U14C](+)-catechin ([U14C](+)-cyanidanol-3) and its metabolite, 3′-O-methyl-(+)-catechin. Xenobiotica 1987; 17: 423–434
  • Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochemical Pharmacology 1983; 32: 1141–1148
  • Illing H. P. A. Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs. Xenobiotica 1981; 11: 815–830
  • Jaworek D., Welsch J. Adenosine 5′-triphosphate. Methods of Enzymatic Analysis3rd Edn., H. U. Bergmeyer. Verlag Chemie, Weinheim 1985; Vol. VII: 340–346
  • Lonchampt M., Guardiola B., Sicot N., Bertrand M., Perdrix L., Duhault J. Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. Arzneimittel-Forschung 1989; 39: 882–885
  • Ratty A. K., Sunamoto J., Das N. P. Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1. Biochemical Pharmacology 1988; 37: 989–995
  • Reddy G. R., Ueda N., Hada T., Sackeyfio A. C., Yamamoto S., Hano Y., Aida M., Nomura T. A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor. Biochemical Pharmacology 1991; 41: 115–118
  • Sacchi Landriani G., Guardabasso V., Rocchetti M. NL-FIT: a microcomputer program for non-linear fitting. Computer Programs in Biomedicine 1983; 16: 35–42
  • Sedlak J., Lindsay R. H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical Biochemistry 1968; 25: 192–205
  • Shali N. A., Curtis C. G., Powell G. M., Roy A. B. Sulphation of the flavonoids quercetin and catechin by rat liver. Xenobiotica 1991; 21: 881–893
  • Sher E., Codignola A., Biancardi E., Cova D., Clementi F. Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines. Pharmacological Research 1992; 26: 1–8
  • Tamura G., Gold C., Ferro-Luzzi A., Ames B. N. Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. Proceedings of the National Academy of Sciences, USA 1980; 77: 4961–4965
  • Valenzuela A., Aspillaga M., Vial S., Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Medica 1989; 55: 420–422
  • Villa P., Corti F., Guaitani A., Bartosek I., Casacci F., De Marchi F., Pacei E. Effects of in vivo treatment with a new fluorinated macrolide (P-0501 A) and other erythromycins on drug clearance and hepatic functions in perfused rat liver. Journal of Antibiotics 1986; 39: 839–845
  • Villa P., Cova D., De Francesco L., Guaitani A., Palladini G., Perego R. Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Toxicology 1992; 73: 179–189
  • Wroblewski F., La Due J. S. Lactic dehydrogenase activity in blood. Proceedings of the Society of Experimental Biological Medicine 1955; 90: 210–213
  • Yamaoka K., Nakagawa T., Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 1978; 6: 165–175

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.