Abstract
Background: The clinical implications of lower body weight in drug using populations are uncertain given that lower mean weights may still fall within the healthy range. Objectives: To determine the effect of type, mode and frequency of drug use on underlying body composition after accounting for differences in body shape and size. Methods: We conducted a cross-sectional analysis of 511 participants from the Tufts Nutrition Collaborative (TNC) Study. Data included measures of body composition, a 24-hour dietary recall, and a detailed health history and lifestyle questionnaire. Multivariate regression analysis was used to determine the independent effect of drug use on percent body fat (BF) after adjusting for BMI and waist circumference. Results: Heavy injection drug users (IDUs) had a 2.6% lower percent BF than non-users after adjusting for BMI, waist circumference, and other confounders. (p = 0.0006). Differences in percent BF were predominantly due to higher lean mass, rather than lower fat mass. Cocaine and heroin had similar effects on body composition. Conclusions: In the U.S., where the general population is prone to over-nutrition, the average percent BF for heavy injectors does not fall into a range low enough to suggest harmful effects. However, in populations with substantial levels of under-nutrition, small differences in percent BF among drug users will have a greater impact on health status. Scientific Significance: Differences in BMI, weight and body composition are not always straightforward. Accounting for underlying nutritional status and relative differences in fat and FFM is critical when interpreting results. diagnosed patients and prevent them from returning to prison.
ACKNOWLEDGMENTS
This work was supported by the National Institutes of Health (NIH), NIDA grants P30DA013868 and R01DA11596; and the General Clinical Research Center funded by the National Center for Research Resources of the NIH under grant M01- RR00054
This was a multi-site study carried out at the following three locations: The Miriam Hospital, Department of Infectious Disease, CFAR/RISE Building, 164 Summit Avenue, Providence, RI 02906, USA; Johns Hopkins School of Medicine, 550 North Broadway, Suite 205, Clinical Trials Unit, Baltimore, MD 21205, USA; Tufts School of Medicine, 150 Harrison Avenue, Jaharis 265, Boston, MA 02111, USA.