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Abstract
Background: Thrombophilia is a multi-factorial disorder caused by inherited and acquired factors. Among the inherited factors are factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T single nucleotide polymorphisms (SNPs).
Aim: The main aim of this study was to assess the incidence of these three SNPs in the Syrian population.
Subjects and methods: A total of 200 unrelated healthy Syrians (100 males and 100 females) were recruited.
Results: The prevalence of factor V G1691A, prothrombin G20210A and MTHFR C677T SNPs among Syrians is 11.5%, 2.5% and 84.5%, respectively. Prevalence of factor V G1691A and prothrombin G20210A SNPs among apparently healthy Syrian individuals is very high.
Conclusion: To the best of the authors knowledge, the Syrian population harbours the highest prevalence of the MTHFR C677T polymorphism compared to all other populations reported so far.
Acknowledgements
We would also like to thank Professor Ibrahim Othman, the Director General of AECS, and Dr Nizar MirAli, Head of Department, for their support. This project was financially supported by Atomic Energy Commission of Syria (AECS).
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.