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Abstract
Background: Knowledge of allele and genotype frequencies is an essential prerequisite to the use of any human polymorphism in forensic work.
Aim: To study the genetic polymorphism and evaluate the application value of nine STR loci.
Subjects and methods: Genotyping of nine STR loci, including D11S2368, D12S391, D13S325, D18S1364, D22-GATA198B05, D6S1043, D2S1772, D7S3048 and D8S1132, of 1050 unrelated individuals was performed with the STR_Typer_10_v1 kit and Genetic Analyzer 3100 and analyzed with PowerState V12.xls and Arlequin ver 3.11 analyzing software.
Results: Allele frequency distribution was statistically analyzed and Hardy–Weinberg equilibrium determined. Several common parameters used in forensic sciences were found: the heterozygosity (H) ranged from 0.827 to 0.892; the matching probability (MP) ranged from 0.029 to 0.074; the power of discrimination (PD) ranged from 0.926 to 0.971; the power of exclusion (PE) ranged from 0.649 to 0.779; the polymorphic information content (PIC) ranged from 0.77 to 0.86; and the typical paternity index (TPI) ranged from 2.88 to 4.62.
Conclusion: The results indicate that nine STR loci are high polymorphic among the Han population in Southern China. This set of polymorphic STR loci is a useful tool in forensic paternity testing and anthropological study.
Acknowledgements
We would like to express our thanks to Chen Weihong for his technical assistance, and Gao Junfeng for collecting samples.
Declaration of interest: This project was supported by the Special Fund for Basic Research from the Ministry of Education PR China (project No. 505015). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.