We would like to discuss on the publication on “Prohepcidin, anemia and inflammatory markers in non-diabetic uremic patients”.Citation1 Aydin et al. reported that “Prohepcidin levels increase with deepening anemia and show positive correlation with inflammatory markers”.Citation1 In fact, there are some previous reports on Prohepcidin and anemia in renal failure. Concluded that “high Prohepcidin levels may be associated with the factors that inhibit erythropoiesis in HD patients”.Citation2 Nevertheless, there are many considerations on the present report. First, the other causes of anemia have not been ruled out in the present study. Some kinds of genetic anemia such as thalassemia affect several studied parameters including iron profile and inflammatory marker.Citation3 Second, the underlying chronic hepatitis has to be ruled out since it can affect the level of Prohepcidin in patient with renal failure. Recently, Caliskan et al. noted for “lower serum Prohepcidin levels associated with lower iron and erythropoietin requirements in hemodialysis patients with chronic hepatitis C”.Citation4
References
- Aydin Z, Gursu M, Karadag S, et al. The relationship of Prohepcidin levels with anemia and inflammatory markers in non-diabetic uremic patients: A controlled study. Ren Fail. 2014;21:1–5
- Eleftheriadis T, Kartsios C, Liakopoulos V, et al. Does hepcidin affect erythropoiesis in hemodialysis patients? Acta Haematol. 2006;116:238–244
- Urrechaga E, Borque L, Escanero JF. Biomarkers of hypochromia: The contemporary assessment of iron status and erythropoiesis. Biomed Res Int. 2013;2013:603786
- Caliskan Y, Yelken B, Ozkok A, et al. Lower serum Prohepcidin levels associated with lower iron and erythropoietin requirements in hemodialysis patients with chronic hepatitis C. BMC Nephrol. 2012;13:56