PROANGIOGENIC CYTOKINES VASCULAR-ENDOTHELIAL GROWTH FACTOR AND BASIC FIBROBLST GROWTH FACTOR IN CHILDHOOD LYMPHADENOPATHY

Abstract

Increased angiogenesis is observed both in the inflammatory and in the neoplasmatic tissue. The aim of the study was to assess the diagnostic significance of serum concentration of vascular-endothelial growth factor (sVEGF) and basic fibroblast growth factor (sbFGF) in the various forms of lymphadenopathy in children. Ninety-four children with lymphadenopathy were studied: group A, 52 patients with lymphadenitis; group B, 42 patients with lymphomas. Group B was divided into subgroups: B_P, children with lymphomas in peripheral lymph nodes and B_M, children with lymphomas in peripheral lymph nodes and mediastinal tumor. The healthy control group was 20 children. Using enzyme-linked immunosorbent assays the authors quantified VEGF and bFGF in serum of healthy children and of children with lymphadenopathy. The sVEGF in group A was significantly higher than controls (313.8 versus 44.6 pg/mL; P <.05) and in group B was 633.4 pg/mL and was significantly higher than controls (P <.0001). The sVEGF and bFGF in group A versus subgroup B_P were significantly lower (P_VEGF <.05, P_bFGF <.05), and sVEGF in subgroup B_P versus B_M was significantly lower (P <.05). These results show that the evaluation of serum VEGF concentration might be useful as noninvasive diagnosis of some chronic peripheral lymphadenopathies in children.

Keywords :

• basic fibroblast growth factor
• children lymphadenitis
• lymphoma
• vascular-endothelial growth factor