Advanced search
Publication Cover
Pediatric Hematology and Oncology Volume 31, 2014 - Issue 5
Submit an article Journal homepage
201
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Single Dose Darbepoetin Alfa is Useful in Reducing Red Cell Transfusions in Leukemic Children Receiving Chemotherapy

Mathew ZachariahDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
,
Mohamed ElshinawyCorrespondence[email protected]
,
Abdulhakim AlrawasDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
,
Wafa BashirDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
,
Ismail ElbeshlawiDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
,
Surekha TonyDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
&
Yasser WaliDepartment of Child Health, College of Medicine, Sultan Qaboos University, Muscat, Oman
 show all
Pages 442-447 | Received 17 Mar 2013, Accepted 09 Jul 2013, Published online: 02 Oct 2013
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

The role of erythropoiesis-stimulating agents (ESAs) in the management of chemotherapy-induced anemia (CIA) is becoming increasingly recognized in the field of medical oncology, with paucity of data in pediatrics. We evaluated the efficacy and tolerability of a single-dose darbepoetin alfa, a long-acting ESA, given to 35 pediatric acute lymphoblastic leukemia (ALL) children during induction chemotherapy. Compared to a retrospective control group, the studied patients have required significantly less units of packed red blood cells (0.88 units/patient in the studied group versus 2.04 units in controls), with no major side effects. We recommend further prospective double-blinded studies with more tailored dosing regimens in pediatric ALL cases and solid tumors.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 636.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.