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Pediatric Hematology and Oncology Volume 9, 1992 - Issue 2
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Review Article

Leukemia in Down Syndrome: A Review

Alvin Zipursky Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, and University of Toronto, Toronto, Ontario, M5G 1X8, Canada
,
Annete Poon Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, and University of Toronto, Toronto, Ontario, M5G 1X8, Canada
&
John Doyle Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, and University of Toronto, Toronto, Ontario, M5G 1X8, Canada
Pages 139-149 | Received 18 Jun 1991, Accepted 15 Aug 1991, Published online: 09 Jul 2009
 
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Abstract

The incidence of leukemia is higher in children with Down syndrome (DS) than in normals. In approximately 50% of cases the type of leukemia is acute megakaryoblastic leukemia (AMKL) and it occurs during the first 4 years of life. The leukemic cell also has features of erythroid progenitors and therefore appears to be a precursor cell with biphenotypic properties.

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