Hemoglobinopathies in the District of Antalya, Turkey

Iffet Bircan Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Sevim Şişli Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Asaf Güven Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Şanda Çali Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Olcay Yeĝin Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Halil Ertuĝ Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Ayfer Gür Güven Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

Nejat Akar Department of Pediatrics, Department of Public Health, Department of Pediatric Hematology, Akdeniz University, Antalya, Turkey

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Abstract

A screening program was conducted to ascertain the incidence of hemoglobinopathies in the district of Antalya, Turkey. The survey sample was selected from the household registration forms of health centers by systematic random sampling. Heparinized blood samples were collected from 1,616 subjects from 884 families.

The prevalence of p thalassemia traits with increased Hb A2 was 10.2%. This is higher than that found in previous studies performed in Antalya. The prevalence of abnormal hemoglobins (Hbs) was found to be 0.8%. Four subjects had Hb AS; five had Hb D-Los Angeles (B 121 [GH4] Glu-Gln); one had Hb Ube-2 (68 [E1] Asn-Asp), one had Hb P-Nilotic (fusion between B 22 and) and two had Hb D-like variants.

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