25
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Signaling Through Gp130: Toward a General Scenario of Cytokine Action

, , , , , & show all
Pages 81-91 | Received 30 Mar 1999, Accepted 17 Jun 1999, Published online: 11 Jul 2009

References

  • Ali S., Chen Z., Lebrun J. J., Vogel W., Kharitonenkov A., Kelly P. A., Ullrich A. PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. EMBO. J. 1996; 15: 135–142
  • Bennett A. M., Hausdorff S. F., O'Reilly A. M., Freeman R. M., Neel B. G. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell Biol. 1996; 16: 1189–1202
  • Besser D., Bromberg J. F., Darnell J. J. E., Hanafusa H. A single amino acid substitution in the v-Eyk intracellular domain results in activation of STAT3 and enhances cellular transformation. Molecular and Cellular Biology 1999; 19: 1401–1409
  • Boeuf H., Hauss C., Graeve F. D., Baran N., Kedinger C. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J. Cell Biol. 1997; 138: 1207–1217
  • Bonni A., Sun Y., Nadal-Vicens M., Bhatt A., Frank D. A., Rozovsky I., Stahl N., Yancopoulos G. D., Greenberg M. E. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 1997; 278: 477–483
  • Boulton T. G., Stahl N., Yancopoulos G. D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 1994; 269: 11648–11655
  • Bromberg J. F., Horvath C. M., Besser D., Lathem W. W., Darnell J. E.J. Stat3 activation is required for cellular transformation by v-src. Mol. Cell Biol. 1998; 18: 2553–2558
  • Carpenter L. R., Farruggella T. J., Symes A., Karow M. L., Yancopoulos G. D., Stahl N. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc. Natl. Acad. Sci. USA 1998; 95: 6061–6066
  • Catlett-Falcone R., Landowski T., Oshiro M., Turkson J., Levitzki A., Savino R., Ciliberto G., Moscinski L., Fernandez-Luna J., Nunez G., Dalton W., Jove R. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 1: 105–115
  • Chung C. D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997; 278: 1803–1805
  • Darnell J. E., Jr. STATs and gene regulation. Science 1997; 277: 1630–1635
  • Endo T. A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., Taniguchi T., Fujita T., Kanakura Y., Komiya S., Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387: 921–924
  • Fujitani Y., Hibi M., Fukada T., Tezuka Takahashi M., Yoshida H., Yamaguchi T., Sugiyama K., Yamanaka Y., Nakajima K., Hirano T. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene 1997; 14: 751–761
  • Fukada T., Hibi M., Yamanaka Y., Takahashi-Tezuka M., Fujitani Y., Yamaguchi T., Nakajima K., Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 1996; 5: 449–460
  • Fukada T., Ohtani T., Yoshida Y., Shirogane T., Nishida K., Nakajima K., Hibi M., Hirano T. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transititon. EMBO. J. 1998; 17: 6670–6677
  • Gerhartz C., Heesel B., Sasse J., Hemmann U., Landgraf C., Schneider-Mergener J., Horn F., Heinrich P. C., Graeve L. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J. Biol. Chem. 1996; 271: 12991–12998
  • Gu H., Pratt J. C., Burakoff S. J., Neel B. G. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Molecular Cell 1998; 2: 729–740
  • Guschin D., Rogers N., Briscoe J., Witthuhn B., Watling D., Horn F., Pellegrini S., Yasukawa K., Heinrich P., Stark G. R., et al. A major role for the protein tyrosine kinase Jakl in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO. L. 1995; 14: 1421–1429
  • Hemmann U., Gerhartz C., Heesel B., Sasse J., Kurapkat G., Grotzinger J., Wollmer A., Zhong Z., Darnell J. E., Jr., Graeve L., Heinrich P. C., Horn F. Differential activation of acute phase response factor/Stat3 and Statl via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. J. Biol. Chem. 1996; 271: 12999–13007
  • Herbst R., Carroll P. M., Allard J. D., Schilling J., Raabe T., Simon M. A. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 1996; 85: 899–909
  • Hibi M., Hirano T. Signal transduction through cytokine receptors (In Process Citation). Int. Rev. Immunol. 1998; 17: 75–102
  • Hirano T. Interleukin 6 and its receptor: Ten years later. Intern. Rev. Immunol. 1998; 16: 249–284
  • Hirano T., Nakajima K., Hibi M. Signaling mechanisms through gp130: A model for the cytokine system. Cytokine & Growth Factor Reviews 1997; 8: 241–252
  • Holgado-Madruga M., Emlet D. R., Moscatello D. K., Godwin A. K., Wong A. J. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 1996; 379: 560–564
  • Ichiba M., Nakajima K., Yamanaka Y., Kiuchi N., Hirano T. Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein. J. Biol. Chem. 1998; 273: 6132–6138
  • Ihara S., Nakajima K., Fukada T., Hibi M., Nagata S., Hirano T., Fukui Y. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO. J. 1997; 16: 5345–5352
  • Ihle J. N., Witthuhn B. A., Quelle F. W., Yamamoto K., Thierfelder W. E., Kreider B., Silvennoinen O. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 1994; 19: 222–227
  • Ingham R. J., Holgado-Madruga M., Siu C., Wong A. J., Gold M. R. The Gabl protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J. Biol. Chem. 1998; 273: 30630–30637
  • Jain N., Zhang T., Fong S. L., Lim C. P., Cao X. Repression of Stat3 activity by activation of mitogenactivated protein kinase (MAPK). Oncogene 1998; 17: 3157–3167
  • Kaplan M. H., Daniel C., Schindler U., Grusby M. J. Stat proteins control lymphocyte proliferation by regulating p27Kipl expression. Mol. Cell Biol. 1998; 18: 1996–2003
  • Kim H., Hawley T. S., Hawley R. G., Baumann H. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells. Mol. Cell Biol. 1998; 18: 1525–1533
  • Kiuchi N., Nakajima K., Ichiba M., Fukada T., Narimatsu M., Mizuno K., Hibi M., Hirano T. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J. Exp. Med. 1999; 189: 63–73
  • Klingmuller U., Lorenz U., Cantley L. C., Neel B. G., Lodish H. F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995; 80: 729–738
  • Li W., Nishimura R., Kashishian A., Batzer A. G., Kim W. J., Cooper J. A., Schlessinger J. A new function for a phosphotyrosine phosphatase:linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell Biol. 1994; 14: 509–517
  • Liu Z. G., Hsu H., Goeddel D. V., Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996; 87: 565–576
  • Liu B., Liao J., Rao X., Kushner S. A., Chung C. D., Chang D. D., Shuai K. Inhibition of Statlmediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 1998; 95: 10626–10631
  • Luo H., Hanratty W. P., Dearolf C. R. An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO. J. 1995; 14: 1412–1420
  • Marengere L. E., Waterhouse P., Duncan G. S., Mittrucker H. W., Feng G. S., Mak T. W. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996, (published errata appear in, 1996, December 6. 274(5293) 1597, and 1997, April 4; 276(5309)21). Science 272, 1170–1173
  • Matsumura I., Ishikawa J., Nakajima K., Oritani K., Tomiyama Y., Miyagawa J., Kato T., Miyazaki H., Matsuzawa Y., Kanakura Y. Thrombopoietininduced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cipl)by STAT5. Mol. Cell Biol. 1997; 17: 2933–2943
  • Metcalf D. Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells. Leukemia 1989; 3: 349–355
  • Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., Akira S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA 1996; 93: 3963–3966
  • Morigg R., Topham D. J., Teglund S., Sexl V., McKay C., Wang D., Hoffmeyer A., van Deursen J., Sangster M. Y., Bunting K. D., Grosveld G. C., Ihle J. N. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999; 10: 249–259
  • Mui A. L., Wakao H., Kinoshita T., Kitamura T., Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO. J. 1996; 15: 2425–2433
  • Murakami M., Narazaki M., Hibi M., Yawata H., Yasukawa K., Hamaguchi M., Taga T., Kishimoto T. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 1991; 88: 11349–11353
  • Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., Nishimoto N., Kajita T., Taga T., Yoshizaki K., Akira S., Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997; 387: 924–929
  • Nakajima K., Matsuda T., Fujitani Y., Kojima H., Yamanaka Y., Nakae K., Takeda T., Hirano T. Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway. Ann. NY Acad. Sci. 1995; 762: 55–70
  • Nakajima K., Yamanaka Y., Nakae K., Kojima H., Ichiba M., Kiuchi N., Kitaoka T., Fukada T., Hibi M., Hirano T. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in Ml leukemia cells. EMBO. J. 1996; 15: 3651–3658
  • Narazaki M., Witthuhn B. A., Yoshida K., Silvennoinen O., Yasukawa K., Ihle J. N., Kishimoto T., Taga T. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc. Natl. Acad. Sci. USA 1994; 91: 2285–2289
  • Neel B. G., Tonks N. K. Protein tyrosine phosphatases in signal transduction. Curr. Opin. Cell Biol. 1997; 9: 193–204
  • Nishida K., Yoshida Y., Itoh M., Fukada T., Ohtani Y. T. S., Astumi T., Takahashi-Tezuka M., Hibi M., Hirano T. Gab-family adaptor proteins act downstream of cytokine and growth factor receptors and T- and B- cell antigen receptors. Blood 1999; 93: 1809–1816
  • Niwa H., Burdon T., Chambers I., Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 1998; 12: 2048–2060
  • Noguchi T., Matozaki T., Horita K., Fujioka Y., Kasuga M. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulinstimulated Ras activation. Mol. Cell Biol. 1994; 14: 6674–6682
  • O'Reilly A. M., Neel B. G. Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction. Mol. CellBiol. 1998; 18: 161–177
  • Ono K., Suga H., Iwabe N., Kuma K., Miyata T. Multiple protein tyrosine phosphatases in sponge and explosive gene duplication in the early evolution of animals before the Parazoan-Eumetazoan split. J. Mol. Evol. 1999; 48: 654–662
  • Paul W. E., Seder R. A. Lymphocyte responses and cytokines. Cell 1994; 76: 241–251
  • Pei D., Wang J., Walsh C. T. Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. Proc. Natl. Acad. Sci. USA 1996; 93: 1141–1145
  • Perkins L. A., Larsen I., Perrimon N. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 1992; 70: 225–236
  • Pregel M. J., Shen S. H., Storer A. C. Regulation of protein tyrosine phosphatase 1C: opposing effects of the two src homology 2 domains. Protein Eng 1995; 8: 1309–1316
  • Raabe T., Riesgo-Escovar J., Liu X., Bausenwein B. S., Deak P., Maroy P., Hafen E. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras 1 in Drosophila. Cell 1996; 85: 911–920
  • Rodig S. J., Meraz M. A., White J. M., Lampe P. A., Riley J. K., Arthur C. D., King K. L., Sheehan K. C., Yin L., Pennica D., Johnson E. M., Jr., Schreiber R. D. Disruption of the Jakl gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998; 93: 373–383
  • Saxton T. M., Henkemeyer M., Gasca S., Shen R., Rossi D. J., Shalaby F., Feng G. S., Pawson T. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO. J. 1997; 16: 2352–2364
  • Schreiber M., Kolbus A., Piu F., Szabowski A., U M. H.-S., Tian J., Karin M., Angel P., Wagner E. F. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 1999; 13: 607–619
  • Sengupta T. K., Talbot E. S., Scherle P. A., Ivashkiv L. B. Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc. Natl. Acad. Sci. USA 1998; 95: 11107–11112
  • Shimoda K., van Deursen J., Sangster M. Y., Sarawar S. R., Carson R. T., Tripp R. A., Chu C., Quelle F. W., Nosaka T., Vignali D. A., Doherty P. C., Grosveld G., Paul W. E., Ihle J. N. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996; 380: 630–633
  • Stahl N., Farruggella T. J., Boulton T. G., Zhong Z., Darnell J. E., Jr., Yancopoulos G. D. Choice of STATs and other substrates specified by modular tyrosinebased motifs in cytokine receptors. Science 1995; 267: 1349–1353
  • Starr R., Willson T. A., Viney E. M., Murray L. J., Rayner J. R., Jenkins B. J., Gonda T. J., Alexander W. S., Metcalf D., Nicola N. A., Hilton D. J. A family of cytokineinducible inhibitors of signalling. Nature 1997; 387: 917–921
  • Symes A., Stahl N., Reeves S. A., Farruggella T., Servidei T., Gearan T., Yancopoulos G., Fink J. S. The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Curr. Biol. 1997; 7: 697–700
  • Takahashi-Tezuka M., Hibi M., Fujitani Y., Fukada T., Yamaguchi T., Hirano T. Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene 1997; 14: 2273–2282
  • Takahashi-Tezuka M., Yoshida Y., Fukada T., Ohtani T., Yamanaka Y., Nishida K., Nakajima K., Hibi M., Hirano T. Gabl acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell Biol. 1998; 18: 4109–4117
  • Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., Nakanishi K., Yoshida N., Kishimoto T., Akira S. Essential role of Stat6 in IL-4 signalling. Nature 1996; 380: 627–630
  • Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., Akira S. Stat3 activation is responsible for IL-6-dependent T-cell proliferation through preventing apoptosis: generation and characterization of T-cell-specific Stat3-deficient mice. J. Immunol. 1998; 161: 4652–4660
  • Tang T. L., Freeman R. M., Jr., O'Reilly A. M., Neel B. G., Sokol S. Y. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 1995; 80: 473–483
  • Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinase. Science 1995; 268: 251–255
  • Thierfelder W. E., van Deursen J. M., Yamamoto K., Tripp R. A., Sarawar S. R., Carson R. T., Sangster M. Y., Vignali D. A., Doherty P. C., Grosveld G. C., Ihle J. N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382: 171–174
  • Thomson A. W. The Cytokine Handbook. Academic Press, London 1998
  • Tonks N. K., Neel B. G. From form to function: signaling by protein tyrosine phosphatases (see comments). Cell 1996; 87: 365–368
  • Turkson J., Bowman T., Garcia R., Caldenhoven E., De Groot R. P., Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell Biol. 1998; 18: 2545–2552
  • Weidner K. M., Di Cesare S., Sachs M., Brinkmann V., Behrens J., Birchmeier W. Interaction between Gabl and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1996; 34: 173–176
  • Wen Z., Zhong Z., Darnell J. E. Maximal activation of transcription by Statl and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82: 241–250
  • White M. F., Yenush L. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr. Top Microbiol Immunol. 1998; 228: 179–208
  • Yamanaka Y., Nakajima K., Fukada T., Hibi M., Hirano T. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO. J. 1996; 15: 1557–1565
  • Yoshimura A., Ohkubo T., Kiguchi T., Jenkins N. A., Gilbert D. J., Copeland N. G., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO. J. 1995; 14: 2816–2826

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.