Abstract
Purpose: The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy.
Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8–476.7 mT peak-to-peak magnetic flux density.
Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group.
Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.
Acknowledgements
This work was supported by the Hungarian National Office for Research and Technology (Innocsekk project KM_CSEKK-2006-00249).
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.