Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base

Abstract

This study described the thermosensitive formulations composed of poloxamer mixtures for use as drug delivery platform via mucosal route. It also characterized the poloxamer mixtures’ rheological, mechanical and mucoadhesive properties. Poloxamer (Plx) 407 and Plx 188 were used alone and together for preparing the mucosal drug delivery platform. The mixtures of Plx 407 and Plx 188 in ratio of 15:15 (F5); 15:20 (F6); 20:10 (F7) existed liquid at room temperature, but gelled at physiological temperature. Flow rheometry studies and oscillatory analysis of each formulation were performed at 20 ± 0.1°C and 37 ± 0.1°C. F5 and F7 formulations exhibited typical gel-type mechanical spectra (G′ > G″) after the determined frequency value at 37°C whereas F6 behaved as weakly cross-linked gel. Texture profile analysis presented that F5 and F7 showed similar mechanical properties and can be used as base for mucosal dosage form. Mucoadhesion studies indicated the difference among the formulations and the effect of the mucosal surface on mucoadhesive properties. Mucin disc, bovine vaginal and buccal mucosa were used as mucosal platform for mucoadhesion studies. It is suggested that these investigations may be usefully combined to provide a more rational basis for selecting the ratio of Plx to prepare a topical thermosensitive drug delivery system for mucosal administration.

Keywords::

• poloxamer
• thermosensitive gel formulation
• texture profile analysis
• oscillation rheometry
• mucoadhesion

Acknowledgements

We would like to thank to Prof. Dr David S. Jones of The Queen’s University of Belfast, School of Pharmacy, Medical Biology Centre, UK, for his excellent collaboration.

Declaration of interest

This work is a part of our research project (No. 106/S/196) supported by The Scientific and Technological Research Council of Turkey (TUBITAK).