Pharmaceutical Development and Technology, Volume 16, Issue 6 (2011)

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Pharmaceutical Development and Technology, Volume 16, Issue 6 (2011)

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Research Article

Article
Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study
Linas N. Mockus, Timothy W. Paul, Nathan A. Pease, Nancy J. Harper, Prabir K. Basu, Elizabeth A. Oslos, Gregory A. Sacha, Wei Y. Kuu, Lisa M. Hardwick, Jacquelyn J. Karty, Michael J. Pikal, Eun Hee, Mansoor A. Khan & Steven L. Nail
Pages: 549-576
Published online: 20 Sep 2011
AbstractforQuality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study | Full Text | References | PDF (1.3 MB)
  • 1031 Views
  • 44 CrossRef citations
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Article
In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols
Barbara D. Alexander, Thomas P. Winkler, Shuai Shi, Elizabeth S. Dodds Ashley & Anthony J. Hickey
Pages: 577-582
Published online: 23 Jun 2011
AbstractforIn vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols | Full Text | References | PDF (762 KB)
  • 302 Views
  • 15 CrossRef citations
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Article
Robustness testing in pharmaceutical freeze-drying: Inter-relation of process conditions and product quality attributes studied for a vaccine formulation
Stefan C. Schneid, Peter M. Stärtzel, Patrick Lettner & Henning Gieseler
Pages: 583-590
Published online: 13 May 2011
AbstractforRobustness testing in pharmaceutical freeze-drying: Inter-relation of process conditions and product quality attributes studied for a vaccine formulation | Full Text | References | PDF (1.2 MB)
  • 413 Views
  • 18 CrossRef citations
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Article
Effect of particle size of parenteral suspensions on in vitro muscle damage
Gayle Brazeau, Shauna L. Sauberan, Larry Gatlin, Peter Wisniecki & Jaymin Shah
Pages: 591-598
Published online: 10 Jan 2011
AbstractforEffect of particle size of parenteral suspensions on in vitro muscle damage | Full Text | References | PDF (770 KB)
  • 555 Views
  • 11 CrossRef citations
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Article
Degree of compression as a potential process control tool of tablet tensile strength
Josefina Nordström & Goran Alderborn
Pages: 599-608
Published online: 22 Jul 2010
AbstractforDegree of compression as a potential process control tool of tablet tensile strength | Full Text | References | PDF (930.3 KB)
  • 241 Views
  • 7 CrossRef citations
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Article
Formulation of a stable and high-loaded quercetin injectable emulsion
Huizhu Sun, Heming Xu, Xinggang Yang, Nan Li, Zhidong Liu, Weisan Pan & Yue Yuan
Pages: 609-615
Published online: 19 Aug 2010
AbstractforFormulation of a stable and high-loaded quercetin injectable emulsion | Full Text | References | PDF (1,006.4 KB)
  • 223 Views
  • 6 CrossRef citations
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Article
Differential heat of adsorption of water vapor on silicified microcrystalline cellulose (SMCC): An investigation using isothermal microcalorimetry
Ken K. Qian & Robin H. Bogner
Pages: 616-626
Published online: 19 Aug 2010
AbstractforDifferential heat of adsorption of water vapor on silicified microcrystalline cellulose (SMCC): An investigation using isothermal microcalorimetry | Full Text | References | PDF (866.8 KB)
  • 127 Views
  • 3 CrossRef citations
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Article
Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base
Esra Baloglu, Sinem Yaprak Karavana, Zeynep Ay Senyigit & Tamer Guneri
Pages: 627-636
Published online: 17 Aug 2010
AbstractforRheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base | Full Text | References | PDF (780 KB)
  • 1364 Views
  • 131 CrossRef citations
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Article
Formulation, characterization and in vitro evaluation of theophylline-loaded Eudragit RS 100 microspheres prepared by an emulsion-solvent diffusion/evaporation technique
Mitra Jelvehgari, Jaleh Barar, Hadi Valizadeh, Sanam Shadrou & Ali Nokhodchi
Pages: 637-644
Published online: 19 Aug 2010
AbstractforFormulation, characterization and in vitro evaluation of theophylline-loaded Eudragit RS 100 microspheres prepared by an emulsion-solvent diffusion/evaporation technique | Full Text | References | PDF (1.3 MB)
  • 226 Views
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Short Report

800 mg Darunavir tablets prepared by hot melt extrusion
Markus Thommes, Lieven Baert & Jan Rosier
Pages: 645-650
Published online: 23 Aug 2010
Abstractfor800 mg Darunavir tablets prepared by hot melt extrusion | Full Text | References | PDF (709.7 KB)
  • 242 Views
  • 9 CrossRef citations
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Technical Note

Article
Comparison between nuclear magnetic resonance profiling and the source/sink approach for characterizing drug diffusion in hydrogel matrices
Marc-André Gagnon & Michel Lafleur
Pages: 651-656
Published online: 05 Aug 2010
AbstractforComparison between nuclear magnetic resonance profiling and the source/sink approach for characterizing drug diffusion in hydrogel matrices | Full Text | References | PDF (801.5 KB)
  • 113 Views
  • 3 CrossRef citations
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