Preparation and characterization of mosapride citrate inclusion complexes with natural and synthetic cyclodextrins

Abstract

The aim of this work was to investigate the inclusion complexes between mosapride citrate and SBE₇β-CD in comparison with the natural β-CD to enhance its bioavailability by improving the solubility and dissolution rate. The complexation efficiency value of SBE₇β-CD was higher than that for β-CD. Solid binary systems of mosapride citrate with CDs were prepared by physical mixing, kneading and freeze-drying techniques at molar ratio of 1:1(drug:CD). Physicochemical characterization of the prepared systems was studied using X-ray diffractometry, differential scanning calorimetry, Fourier-transform infrared spectroscopy and scanning electron microscopy (SEM). Amorphous drug was detectable to large extent in inclusion complexes prepared using the freeze-drying technique. From the dissolution study of different inclusion complexes in simulated saliva solution (pH 6.8), we could concluded that irrespective of the preparation technique, the systems prepared using SBE₇β-CD showed better performance than the corresponding ones prepared using β-CD. In addition, the freeze-drying technique showed superior dissolution enhancement than other methods especially when combined with the SBE₇β-CD

Keywords::

• Mosapride citrate
• cyclodextrins
• inclusion complexes
• physicochemical characterization
• in vitro dissolution

Acknowledgments

The authors wish to acknowledge Marcyrl pharma (Egypt) for the provision of Mosapride citrate. The authors are grateful to Cydex pharmaceuticals (USA) for providing SBE₇β-CD as a gift sample. The authors are also grateful to Roquette (France) for the gift sample of β-CD.

Declaration of interest

The authors report no declarations of interest.