Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians

Abstract

Objectives: The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians.

Methods: We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance.

Results: None of the polymorphisms showed a statistically significant association with the risk of varicose veins.

Conclusions: Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians.

Keywords:

• Association
• folate-metabolizing genes
• SNP

Acknowledgements

The authors thank Laboratory of Pharmacogenomics team for help with statistical analysis.

Disclosure statement

The authors report that they have no conflicts of interest.

Funding information

This work was supported by Russian Science Fund (Grant no. 14-15-00734, “Searching of genes involved in varicose vein disease pathology”) and by Presidium of the Siberian Branch of the Russian Academy of Sciences (Project no. 16, “Identification of key regulatory genes involved in the pathogenesis of varicose veins using the complex methods of bioinformatical and experimental transcriptome analysis”).