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Research Article

Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians

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Pages 619-624 | Received 24 Apr 2015, Accepted 14 Mar 2016, Published online: 21 Apr 2016

References

  • Austin RC, Lentz SR, Werstuck GH. (2004). Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 11:S56–64.
  • Balding DJ. (2006). A tutorial on statistical methods for population association studies. Nat Rev Genet 7:781–91.
  • Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. (2005). The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol 15:175–84.
  • Belkovets AV, Kurilovich SA, Agarwal DP. (2001). Methylenetetrahydrofolate reductase (MTHFR). Incidence of the C677T mutation in a Siberian female population. Anthropol Anz 59:19–25.
  • Bellamy MF, McDowell IF, Ramsey MW, et al. (1998). Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98:1848–52.
  • Beskorovaĭnaia TS, Gudzenko SV, Tverskaia SM, Poliakov AV. (2006). The association of polymorphic alleles of folate metabolism genes with recurrent pregnancy loss. Russ J Hum Reprod 1:53–66.
  • Chen J, Stampfer MJ, Ma J, et al. (2001). Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 154:667–72.
  • Clarke GM, Anderson CA, Pettersson FH, et al. (2011). Basic statistical analysis in genetic case–control studies. Nat Protoc 6:121–33.
  • Darvall KAL, Sam RC, Adam DJ, et al. (2009). Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls. J Vasc Surg 49:1235–41.
  • Dong D, Wang B, Yin W, et al. (2013). Disturbance of copper homeostasis is a mechanism for homocysteine-induced vascular endothelial cell injury. PLoS One 8:e76209.
  • Eklöf B, Rutherford RB, Bergan JJ, et al. (2004). Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 40:1248–52.
  • Fredriksen A, Meyer K, Ueland PM, et al. (2007). Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 28:856–65.
  • Ganguly P, Alam SF. (2015). Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6.
  • Ghaderian SMH, Khodaii Z. (2012). Tissue remodeling investigation in varicose veins. Int J Mol Cell Med 1:50–61.
  • Gohil R, Peck G, Sharma P. (2009). The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. Thromb Haemost 102:360–70.
  • Gurda D, Handschuh L, Kotkowiak W, Jakubowski H. (2015). Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells. Amino Acids 47:1319–39.
  • Guzik B, Chwała M, Matusik P, et al. (2011). Mechanisms of increased vascular superoxide production in human varicose veins. Pol Arch Med Wewnętrznej 121:279–86.
  • Hamdan A. (2012). Management of varicose veins and venous insufficiency. JAMA 308:2612–21.
  • Harmon DL, Shields DC, Woodside JV, et al. (1999). Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 17:298–309.
  • Holmes MV, Newcombe P, Hubacek JA, et al. (2011). Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet 378:584–94.
  • Hou X, Chen X, Shi J. (2015). Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: a meta-analysis. Gene 565:39–44.
  • Kim C-S, Kim Y-R, Naqvi A, et al. (2011). Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc. Cardiovasc Res 92:466–75.
  • Lentz SR. (1997). Homocysteine and vascular dysfunction. Life Sci 61:1205–15.
  • Lentz SR, Sobey CG, Piegors DJ, et al. (1996). Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 98:24–9.
  • Lim CS, Davies AH. (2009). Pathogenesis of primary varicose veins. Br J Surg 96:1231–42.
  • Montjean D, Benkhalifa M, Dessolle L, et al. (2011). Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts. Fertil Steril 95:635–40.
  • Nazarenko MS, Puzyrev VP, Kazantseva OM, et al. (2009). Folate-metabolizing genes and breast cancer risk. Meditsinskaya Genet 1:31–7.
  • Paré G, Chasman DI, Parker AN, et al. (2009). Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women’s Genome Health Study. Circ Cardiovasc Genet 2:142–50.
  • Pfisterer L, König G, Hecker M, Korff T. (2014). Pathogenesis of varicose veins-lessons from biomechanics. VASA 43:88–99.
  • Raffetto JD, Khalil RA. (2008). Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology 23:85–98.
  • Rozen R. (1997). Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 78:523–6.
  • Sam RC, Burns PJ, Hobbs SD, et al. (2003). The prevalence of hyperhomocysteinemia, methylene tetrahydrofolate reductase C677T mutation, and vitamin B12 and folate deficiency in patients with chronic venous insufficiency. J Vasc Surg 38:904–8.
  • Segiet OA, Brzozowa M, Piecuch A, et al. (2014). Biomolecular mechanisms in varicose veins development. Ann Vasc Surg 29:377–84.
  • Selçuk Kapısız N, Uzun Kulaoğlu T, Fen T, Kapısız HF. (2014). Potential risk factors for varicose veins with superficial venous reflux. Int J Vasc Med 2014:531689.
  • Sverdlova AM, Bubnova NA, Baranovskaya SS, et al. (1998). Prevalence of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with varicose veins of lower limbs. Mol Genet Metab 63:35–6.
  • Virdis A, Ghiadoni L, Cardinal H, et al. (2001). Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension. J Am Coll Cardiol 38:1106–15.
  • Virdis A, Iglarz M, Neves MF, et al. (2003). Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arterioscler Thromb Vasc Biol 23:1352–7.
  • Wald DS, Law M, Morris JK. (2002). Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325:1202.
  • Weiner AS, Boyarskih UA, Voronina EN, et al. (2010). Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR and C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in the West Siberian Region of Russia. Mol Biol 44:720–7.
  • Weiner AS, Boyarskikh UA, Voronina EN, et al. (2014a). Polymorphisms in folate-metabolizing genes and risk of idiopathic male infertility: a study on a Russian population and a meta-analysis. Fertil Steril 101:87–94.e3.
  • Weiner AS, Boyarskikh UA, Voronina EN, et al. (2014b). Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level. Gene 533:168–72.
  • Weiner AS, Gordeeva LA, Voronina EN, et al. (2012). Polymorphisms in folate-metabolizing genes and risk of having an offspring with congenital anomalies in the West Siberian region of Russia: a case-control study. Prenat Diagn 32:1041–8.
  • Wilmanns C, Casey A, Schinzel H, Walter PK. (2011). Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. Phlebology 26:135–9.
  • Wu S, Gao X, Yang S, et al. (2015). The role of endoplasmic reticulum stress in endothelial dysfunction induced by homocysteine thiolactone. Fundam Clin Pharmacol 29:252–9.
  • Yasim A, Kilinc M, Aral M, et al. (2008). Serum concentration of procoagulant, endothelial and oxidative stress markers in early primary varicose veins. Phlebology 23:15–20.
  • Zhang D, Chen Y, Xie X, et al. (2012). Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol 53:487–96.
  • Zhang P, Gao X, Zhang Y, et al. (2015). Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population: a meta-analysis of 24 case-controlled studies. Angiology 66:422–32.

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