Relationship between serum uric acid levels and metabolic syndrome in Chinese postmenopausal women

Abstract

Objective Serum uric acid levels have been reported to be associated with metabolic syndrome (MetS). However, few studies specifically examining the relationship between serum uric acid (SUA) levels and MetS in postmenopausal women have been reported in China. Thus, we conducted this study in order to assess the relationship between SUA levels and MetS in Chinese postmenopausal women.

Methods A cross-sectional study of 1022 Chinese postmenopausal women (aged 42–80 years) who participated in annual health check-ups was employed. MetS was defined by National Cholesterol Education Program/Adult Treatment Panel III criteria (NCEP-ATP III). Of all the participants, 385 women were diagnosed with MetS (MetS group) and the others were without MetS (non-MetS group). SUA quartiles were defined as follows: Q1, < 3.9 mg/dl; Q2, 3.9–4.5 mg/dl; Q3, 4.6–5.1 mg/dl; Q4, 5.2–6.0 mg/dl. The association between SUA quartiles and MetS was assessed using binary logistic regression.

Results The adjusted odds ratio (95% confidence interval) for the presence of metabolic syndrome in the highest SUA quartile vs. the lowest quartile was 3.768 (2.386–5.950) for all women (p < 0.01) after adjusting for age, body mass index, blood urea nitrogen, serum creatinine, total cholesterol, low density lipoprotein cholesterol and C-reactive protein. The presence of MetS significantly increased in the second, third and fourth quartiles of SUA. The prevalence of MetS increased gradually with an increasing serum uric acid quartile (p for trend < 0.001).

Conclusion Higher SUA levels are positively and independently associated with the presence of MetS in Chinese postmenopausal women.

Key words::

• METABOLIC SYNDROME
• MENOPAUSE
• URIC ACID
• WOMEN

ACKNOWLEDGEMENTS

We thank all the participants. We gratefully acknowledge the Department of Medical Examination Center, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College.

Conflict of interest The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Source of funding The study was financially supported by Scientific research fund, Department of Clinical Nutrition, Department of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College.