Abstract
1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to ‘classical’ CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
Acknowledgements
This article is taken in part from the PhD thesis of Rajendra Rathman 2010. John Spencer (James Black Foundation 2001–2006) would like to dedicate this article to the memory of Sir James Black, Nobel Laureate, deceased 2010, for his outstanding contributions to medicinal chemistry.
Financial & competing interests disclosure
John Spencer would like to thank the University of Greenwich, Royal Society of Chemistry, BP, Novartis and Avexa for funding. The EPSRC units at Swansea (mass spectrometry) and Southampton (x-ray) have been instrumental in helping advance our research. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.