Future Medicinal Chemistry, Volume 2, Issue 9 (2010)

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Future Medicinal Chemistry, Volume 2, Issue 9 (2010)

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News & Analysis

News
News & Analysis
Pages: 1387-1389
Published online: 13 Sep 2010
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News
Development and Application of a High-Throughput Formulation Screening Strategy for Oral Administration in Drug Discovery
Suma Gopinathan, Amr Nouraldeen & Alan G E Wilson
Pages: 1391-1398
Published online: 13 Sep 2010
AbstractforDevelopment and Application of a High-Throughput Formulation Screening Strategy for Oral Administration in Drug Discovery | Full Text | References | PDF (759.6 KB)
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News
Opinion: The Future of Pharmaceutical R&D: Somewhere Between Open and Reverse Innovation?
Patrice Talaga
Pages: 1399-1403
Published online: 13 Sep 2010
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News
Opinion: Why Traditional Knowledge is Important in Drug Discovery
Graham Dutfield
Pages: 1405-1409
Published online: 13 Sep 2010
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News
Opinion: Open Innovation: An Answer for Neglected Diseases
Sanchayita Kar
Pages: 1411-1415
Published online: 13 Sep 2010
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Preliminary Communication

Brief Report
Gram-Scale Synthesis of the P38α MAPK-Inhibitor VX-745 for Preclinical Studies into Werner Syndrome
Mark C Bagley, Terence Davis, Matthew C Dix, Vincenzo Fusillo, Morgane Pigeaux, Michal J Rokicki & David Kipling
Pages: 1417-1427
Published online: 13 Sep 2010
AbstractforGram-Scale Synthesis of the P38α MAPK-Inhibitor VX-745 for Preclinical Studies into Werner Syndrome | Full Text | References | PDF (1,018.7 KB)
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Perspective

Article
Drug Discovery and Development for Spinal Muscular Atrophy: Lessons from Screening Approaches and Future Challenges for Clinical Development
Rebecca M Pruss, Marc Giraudon-Paoli, Svetlana Morozova, Patrick Berna, Jean-Louis Abitbol & Thierry Bordet
Pages: 1429-1440
Published online: 13 Sep 2010
AbstractforDrug Discovery and Development for Spinal Muscular Atrophy: Lessons from Screening Approaches and Future Challenges for Clinical Development | Full Text | References | PDF (1.5 MB)
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Review

Review Article
1,4-Benzodiazepin-2-Ones in Medicinal Chemistry
John Spencer, Rajendra P Rathnam & Babur Z Chowdhry
Pages: 1441-1449
Published online: 13 Sep 2010
Abstractfor1,4-Benzodiazepin-2-Ones in Medicinal Chemistry | Full Text | References | PDF (1.2 MB)
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Review Article
Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-Ray Crystallography and NMR
Sean C Gay, Arthur G Roberts & James R Halpert
Pages: 1451-1468
Published online: 13 Sep 2010
AbstractforStructural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-Ray Crystallography and NMR | Full Text | References | PDF (997.7 KB)
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Review Article
Recent Advances in the Design and Synthesis of Heterocycles as Anti-Tubercular Agents
Prem M S Chauhan, Naresh Sunduru & Moni Sharma
Pages: 1469-1500
Published online: 13 Sep 2010
AbstractforRecent Advances in the Design and Synthesis of Heterocycles as Anti-Tubercular Agents | Full Text | References | PDF (1.2 MB) | Supplemental
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Acknowledgements

Acknowledgements
Page: 1501
Published online: 13 Sep 2010
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