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Review

The RNA polymerase II preinitiation complex

Through what pathway is the complex assembled?

Article: e27050 | Received 26 Sep 2013, Accepted 02 Nov 2013, Published online: 15 Nov 2013
 

Abstract

The general transcription factors required for the assembly of the RNA polymerase II preinitiation complex at TATA-dependent promoters are well known. However, recent studies point to two quite distinct pathways for assembly of these components into functional transcription complexes. In this review, the two pathways are compared and potential implications for gene regulatory mechanisms are discussed.

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

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