NMR and QSAR studies on the transacylation reactivity of model 1β-O-acyl glucuronides. I: design, synthesis and degradation rate measurement

S. J. Vanderhoeven Biological Chemistry, Biological Sciences Division, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK

J. C. Lindon Biological Chemistry, Biological Sciences Division, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UKCorrespondence[email protected]

J. Troke Biological Chemistry, Biological Sciences Division, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK

G. E. Tranter Biological Chemistry, Biological Sciences Division, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK

I. D. Wilson DMPK, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK

J. K. Nicholson Biological Chemistry, Biological Sciences Division, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK

NMR and QSAR studies on the transacylation reactivity of model 1β-O-acyl glucuronides. I: design, synthesis and degradation rate measurement

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NMR and QSAR studies on the transacylation reactivity of model 1β-O-acyl glucuronides. I: design, synthesis and degradation rate measurement

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