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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 3
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Research Article

Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandinΔ13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the α,β-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670

K. Itoh Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University, Sendai, Japan
,
K. Yamamoto Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University, Sendai, Japan
,
M. Adachi Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University, Sendai, Japan
,
T. Kosaka Core Technology Research Laboratories, Daiichi-Sankyo Co. Ltd, Tokyo, Japan
&
Y. Tanaka Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University, Sendai, Japan
Pages 249-263 | Received 22 Aug 2007, Accepted 24 Oct 2007, Published online: 22 Sep 2008

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