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Xenobiotica

the fate of foreign compounds in biological systems

Volume 38, 2008 - Issue 7-8: Special Issue: Xenobiotic and Endobiotic Transporters: Structure, Function and Regulation

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Research Article

Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions

R. Elsby Development Drug Metabolism and Pharmacokinetics & Bioanalysis–Charnwood, AstraZeneca Research & Development Charnwood, Loughborough, UK

D. D. Surry Development Drug Metabolism and Pharmacokinetics & Bioanalysis–Charnwood, AstraZeneca Research & Development Charnwood, Loughborough, UK

V. N. Smith Development Drug Metabolism and Pharmacokinetics & Bioanalysis–Charnwood, AstraZeneca Research & Development Charnwood, Loughborough, UK

A. J. Gray Development Drug Metabolism and Pharmacokinetics & Bioanalysis–Charnwood, AstraZeneca Research & Development Charnwood, Loughborough, UK

Pages 1140-1164 | Received 30 Jan 2008, Accepted 12 Mar 2008, Published online: 22 Sep 2008

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https://doi.org/10.1080/00498250802050880

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