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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 9
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Research Article

Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

C. R. GibsonDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, PA, USACorrespondence[email protected]
,
A. BergmanDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, PA, USA
,
P. LuDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, PA, USA
,
F. KesisoglouDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, PA, USA
,
W. S. DenneyDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, PA, USA
&
E. MulrooneyMerck Research Laboratories, Montreal, Canada
Pages 637-648 | Received 02 Mar 2009, Accepted 07 Apr 2009, Published online: 29 May 2009

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