Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

Li WangCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China,

Xiaodan HongCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China,

Zhihong YaoCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China, Correspondence[email protected] [email protected]

Yi DaiCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China,

Guoping ZhaoIntegrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, P.R. China, and

Zifei QinCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, P.R. China, and Correspondence[email protected]

Baojian WuCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, P.R. China, and

Frank J. GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Xinsheng YaoCollege of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China, ;Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, P.R. China, and

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Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

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Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

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