Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model

Yannick ParmentierDepartment of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France, Correspondence[email protected]

Corinne PothierDepartment of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France,

Nicola HewittScientific Writing Services, Erzhausen, Germany,

Ludwig VincentDepartment of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France,

Fabrice CaradecDepartment of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France,

Jia LiuSIMM-SERVIER Joint Biopharmacy Laboratory, Shanghai Institute of Materia Medica, Shanghai, China,

Feifei LinSIMM-SERVIER Joint Biopharmacy Laboratory, Shanghai Institute of Materia Medica, Shanghai, China,

Marie-Michèle TrancartEurosafe, Saint-Grégoire, France, and

Fabrice GuilletEurosafe, Saint-Grégoire, France, and

Belkacem BouaitaBiopredic International, Rennes, France

Christophe ChesneBiopredic International, Rennes, France

Bernard WaltherDepartment of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France,

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