Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

Haruna NagayoshiOsaka Institute of Public Health, Osaka, Japan; View further author information

Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan; View further author information

Masaki TsujinoOsaka Institute of Public Health, Osaka, Japan; View further author information

Shigeo TakenakaGraduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino, Osaka, Japan; View further author information

Jun KatahiraLaboratory of Cellular and Molecular Biology, Veterinary Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan; View further author information

Vitchan KimDepartment of Biological Sciences, Konkuk University, Seoul, Korea, and; View further author information

Donghak KimDepartment of Biological Sciences, Konkuk University, Seoul, Korea, and;

Masayuki KomoriLaboratory of Cellular and Molecular Biology, Veterinary Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan; View further author information

Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan;

F. Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA

Tsutomu ShimadaLaboratory of Cellular and Molecular Biology, Veterinary Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan; Correspondence[email protected]
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