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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 12
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General Xenobiochemistry

Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver

Yongjie Zhanga Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China;b WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan
,
Rei Satoc Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
,
Tatsuki Fukamib WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan;c Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
,
Masataka Nakanob WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan;c Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
&
Miki Nakajimab WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan;c Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, JapanCorrespondence[email protected]
Pages 1352-1359 | Received 06 Sep 2021, Accepted 14 Nov 2021, Published online: 30 Nov 2021

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