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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 2
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General Xenobiochemistry

Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist

Motoki OchiDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, JapanCorrespondence[email protected]
,
Kohnosuke KinoshitaDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, JapanORCID Iconhttps://orcid.org/0000-0003-4026-5129
ORCID Icon,
Jun-ichi YamaguchiDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan
&
Hiromi EndoDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan
Pages 119-128 | Received 08 Jan 2022, Accepted 12 Mar 2022, Published online: 29 Mar 2022

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