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Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 2
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Clinical Pharmacokinetics and Metabolism

Development and validation of an LC-MS/MS method for simultaneous determination of SH-1028, an irreversible third-generation EGFR TKI, and two of its metabolites in human plasma: application in clinical pharmacokinetics

Sufeng Zhoua Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaView further author information
,
Bijun Shaa Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;b Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Lu Wanga Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaView further author information
,
Yuqing Zhaoa Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaView further author information
,
Zhiqiang Wangc Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, ChinaView further author information
,
Xian Zhangc Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, ChinaView further author information
,
Luwei Hanc Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, ChinaView further author information
,
Feng Shaoa Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;d Department of Clinical Pharmacology, Pharmacy College, Nanjing Medical University, Nanjing, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Xijing Chenb Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
View further author information
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Pages 84-92 | Received 29 Dec 2022, Accepted 18 Feb 2023, Published online: 08 Mar 2023

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