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Xenobiotica

the fate of foreign compounds in biological systems

Volume 54, 2024 - Issue 2

233

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Animal Pharmacokinetics and Metabolism

Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human

Laurent Salphatia Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USACorrespondence[email protected]
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Jodie Panga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information

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Bruno Alickeb Translational Oncology, Genentech, Inc, South San Francisco, CA, USA; ;View further author information

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Emile G. Plisea Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information

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Jonathan Cheonga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information

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Allan Jaochicoa Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information

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Alan G. Oliveroc Chemistry, Genentech, Inc, South San Francisco, CA, USAView further author information

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Deepak Sampathb Translational Oncology, Genentech, Inc, South San Francisco, CA, USA; ;View further author information

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Susan Wonga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information

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Xiaolin Zhanga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAView further author information