Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin

Chenchen BingDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; Correspondence[email protected]
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Pratik PatelChildren’s Health, Dallas, TX, USA; View further author information

Robert M. StaruchDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; ;Profound Medical, Mississauga, ON, Canada; View further author information

Sumbul ShaikhDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Joris NofieleDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Michelle Wodzak StaruchDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Debra SzczepanskiDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Noelle S. WilliamsDepartment of Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Theodore LaetschChildren’s Health, Dallas, TX, USA; ;Department of Pediatrics, Division of Hematology-Oncology and Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA; View further author information

Rajiv ChopraDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; ;Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA