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Annals of Medicine Volume 54, 2022 - Issue 1
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Gastroenterology & Hepatology

Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study

Narmeen Mallaha Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain;b WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Spain;c Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain;d Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Carlos III Health Institute, Madrid, SpainCorrespondence[email protected]
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Maruxa Zapata-Cachafeiroa Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain;e Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Carlos III Health Institute, Madrid, SpainView further author information
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Carmelo Aguirref Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain;g Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, Spain;h Pharmacology Department, Medicine and Nursing Faculty, University of the Basque Country, Barakaldo, SpainView further author information
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Eguzkiñe Ibarra-Garcíaf Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain;i Osakidetza Basque Health Service, Pharmacy Department, Urduliz Hospital, Urduliz, SpainView further author information
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Itziar Palacios-Zabalzaf Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain;g Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, SpainView further author information
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Fernando Macías-Garcíaj Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, SpainView further author information
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María Piñeiro-Lamase Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Carlos III Health Institute, Madrid, Spain;k Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainView further author information
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Luisa Ibáñezl Department of Pharmacology, Therapeutics and Toxicology, Catalonian Institute of Pharmacology, Clinical Pharmacology Service, Vall d’Hebron University Teaching Hospital, Autonomous University, Barcelona, SpainView further author information
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Xavier Vidall Department of Pharmacology, Therapeutics and Toxicology, Catalonian Institute of Pharmacology, Clinical Pharmacology Service, Vall d’Hebron University Teaching Hospital, Autonomous University, Barcelona, SpainView further author information
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Lourdes Vendrelll Department of Pharmacology, Therapeutics and Toxicology, Catalonian Institute of Pharmacology, Clinical Pharmacology Service, Vall d’Hebron University Teaching Hospital, Autonomous University, Barcelona, SpainView further author information
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Luis Martin-Ariasm Centre for Research on Drug Safety (CESME), Valladolid University, Valladolid, SpainView further author information
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María Sáinz-Gilm Centre for Research on Drug Safety (CESME), Valladolid University, Valladolid, SpainView further author information
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Verónica Velasco-Gonzálezm Centre for Research on Drug Safety (CESME), Valladolid University, Valladolid, SpainView further author information
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Manuel Bacariza-Cortiñasn Centro de Saúde de Vite, Santiago de Compostela, SpainView further author information
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Angel Salgadoa Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, SpainView further author information
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Ana Estany-Gestalk Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainView further author information
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Adolfo Figueirasa Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain;e Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Carlos III Health Institute, Madrid, Spain;k Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainView further author information
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Pages 379-392 | Received 26 Aug 2021, Accepted 05 Dec 2021, Published online: 04 Feb 2022

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