Active CD4⁺ helper T cells directly stimulate CD8⁺ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes

Zhenmin Ye Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Khawaja Ashfaque Ahmed Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Zhenmin Ye Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Siguo Hao Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Xueshu Zhang Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Yufeng Xie Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Manju Ankathatti Munegowda Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Qinghe Meng Department of Pathology, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Rajni Chibbar Department of Pathology, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

Jim Xiang Research Unit, Departments of Oncology and Immunology, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Sask., Canada, S7N 4H4

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Active CD4⁺ helper T cells directly stimulate CD8⁺ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes

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Active CD4+ helper T cells directly stimulate CD8+ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes

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Active CD4⁺ helper T cells directly stimulate CD8⁺ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes