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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 3
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Research Articles

Global optimization of the Michaelis–Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats

Marina V. EvansORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA; Correspondence[email protected]
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,
Christopher R. EklundORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA; View further author information
,
David N. WilliamsORISE, Oak Ridge Institute for Science and Education, Oak Ridge, TN, USAView further author information
,
Yusupha M. SeyORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA; View further author information
&
Jane Ellen SimmonsORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA; View further author information
Pages 97-109 | Received 16 Aug 2019, Accepted 08 Mar 2020, Published online: 02 Apr 2020

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